PMID: 11342967May 9, 2001Paper

Evidence of a peripheral role of neurokinins in detrusor hyperreflexia: a further study of selective tachykinin antagonists in chronic spinal injured rats

The Journal of Urology
M Abdel-GawadM M Elhilali

Abstract

Spinal cord injury above the sacral micturition center usually leads to detrusor hyperreflexia, increased intravesical pressure and post-void residual urine. Detrusor hyperreflexia is believed to be mediated by afferent C fibers with tachykinins as neurotransmitters. We investigated the selective peptide tachykinin antagonists MEN 11420 and GR 82334 of NK-2 and NK-1 receptors, respectively, in a chronic rat model of detrusor hyperreflexia after suprasacral spinal cord injury. Adult female Sprague-Dawley rats weighing 200 to 250 gm. were used. The spinal cord was transected at the T10 level. The bladder was evacuated by the Credé maneuver 3 times daily. After 6 weeks the rats were implanted with femoral vein and bladder dome catheters 2 days before filling cystometry. The 5 rats in group 1 received 100 nmol./kg. of the NK-2 antagonist MEN 11420 intravenously. The 5 rats in group 2 received 100 nmol./kg. of the NK-1 antagonist GR 82334 intravenously. The 5 rats in group 3 received a combination of the same dose of each antagonist. Three repetitive micturition cycles were recorded before injection. Three micturition cycles were done 20 minutes after the injection of each antagonist. Mean cystometric parameters were reported, inclu...Continue Reading

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Citations

Nov 5, 2003·Neurourology and Urodynamics·Hassan ShakerMostafa Elhilali
Jan 16, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Emilio SaccoPierfrancesco Bassi
Jul 4, 2012·International Urogynecology Journal·Alana M MurphyHoward B Goldman
Jun 28, 2012·The Journal of Pharmacology and Experimental Therapeutics·Xiulin ZhangWilliam C de Groat
Jul 11, 2007·Postgraduate Medical Journal·Sushma SrikrishnaMaria Vella
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Alessandro Lecci, Carlo Alberto Maggi
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Russell Chess-Williams
Mar 11, 2009·Expert Review of Neurotherapeutics·Pamela A McCombeMichael W Jackson
Aug 19, 2006·Expert Opinion on Investigational Drugs·Atul Tiwari, Krishna S Naruganahalli
Dec 22, 2004·The Prostate·Paul D WaldenAnindya Bhattacharya
May 6, 2016·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Dec 14, 2004·Life Sciences·Luz CandenasJocelyn N Pennefather
Jan 24, 2006·European Urology·Karl-Erik Andersson
Nov 18, 2003·BJU International·L TemplemanR Chess-Williams
Sep 8, 2005·The Journal of Urology·Aly M Abdel-KarimMostafa M Elhilali

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