Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis

PloS One
Gloria Sanchez-AntolínJesus F Bermejo-Martin

Abstract

The role of systemic immunity in the pathogenesis of cirrhosis is not fully understood. Analysis of transcriptomic profiles in blood is an easy approach to obtain a wide picture of immune response at the systemic level. We studied gene expression profiles in blood from thirty cirrhotic patients and compared them against those of eight healthy volunteers. Most of our patients were male [n = 21, 70%] in their middle ages [57.4 ± 6.8 yr]. Alcohol abuse was the most frequent cause of cirrhosis (n = 22, 73%). Eleven patients had hepatocellular carcinoma (36.7%). Eight patients suffered from hepatitis C virus infection (26.7%). We found a signature constituted by 3402 genes which were differentially expressed in patients compared to controls (2802 over-expressed and 600 under-expressed). Evaluation of this signature evidenced the existence of an active pro-fibrotic transcriptomic program in the cirrhotic patients, involving the [extra-cellular matrix (ECM)-receptor interaction] & [TGF-beta signaling] pathways along with the [Cell adhesion molecules] pathway. This program coexists with alterations in pathways participating in [Glycine, serine and threonine metabolism], [Phenylalanine metabolism], [Tyrosine metabolism], [ABC transporte...Continue Reading

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Citations

Jun 16, 2019·The Journal of Nutritional Biochemistry·Melissa M HeintzWilliam S Baldwin
Aug 31, 2021·The International Journal of Biochemistry & Cell Biology·Chuin Ying UngTanya J Shaw

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Methods Mentioned

BETA
chip
PCR
biopsies

Software Mentioned

DAVID
GeneSpring
Graphite Web
DAVID ( Database for Annotation , Visualization , and Integrat...

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