PMID: 7263443Aug 1, 1981Paper

Evidence of active regulation of cerebrospinal fluid acid-base balance

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
S W BledsoeT F Hornbein

Abstract

To test the passive transport hypothesis of cerebrospinal fluid (CSF) [H+] regulation, we altered the relationship between plasma [H+] and the electrical potential difference between CSF and blood (PD) by elevating plasma [K+] during 6-h systemic acid-base disturbances. In five groups of pentobarbital-anesthetized dogs, we increased plasma [K+] from 3.5 to an average of 7.8 meq/l. Hyperkalemia produced an increase in the PD of 6.3 mV by 6 h with normal plasma acid-base status (pHa 7.4), of 8.3 mV with isocapnic metabolic acidosis (pHa 7.2), of 5.3 mV with isocapnic metabolic alkalosis (pHa 7.6), of 9.2 mV with isobicarbonate respiratory acidosis (PaCO2 61 Torr) and of 5.7 mV with isobicarbonate respiratory alkalosis (PaCO2 25 Torr). The change in CSF [H+] at 6 h in each group was the same as that observed in normokalemic animals (Am. J. Physiol. 228: 1134-1154, 1975). This result is not consistent with the passive transport hypothesis. The CSF-blood PD is therefore not an important determinant of CSF [H+] CSF [H+] homeostasis must result from some form of active transport control.

Citations

Mar 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·R Shukla, S B Shukla

Related Concepts

Anion Gap
Metabolic Acidosis
Acidosis, Respiratory
Alkalosis
Alkalosis, Respiratory
Cerebrospinal Fluid
Canis familiaris
Hyperkalemia

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

American Journal of Respiratory and Critical Care Medicine
S JavaheriJ M Adams
Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
S JavaheriI Leusen
© 2021 Meta ULC. All rights reserved