Evidence of altered corticomotor system connectivity in early-stage Alzheimer's disease.

Journal of Neurologic Physical Therapy : JNPT
Eric D VidoniJeffrey M Burns

Abstract

There is increasing evidence for subtle motor dysfunction early in Alzheimer disease (AD), including common motor behaviors that were once considered unaffected early in the disease process. Our objective was to assess whether functional neural networks underlying motor behavior are altered by AD. We investigated AD-related differences in regional brain activation during motor performance. Nine older adults with early-stage AD and 10 without dementia underwent functional magnetic resonance imaging while performing a visually directed simple motor task (hand squeeze). Despite some similarity in brain activation during motor performance, we found that individuals without dementia exhibited greater activation in accessory motor regions, supplementary motor area, and cerebellum compared with those with AD. We also assessed disease-related differences in regions where activity was functionally integrated with primary motor cortex. Using a psychophysiological interaction analysis, we found that those with AD displayed increased coactivation with primary motor cortex of bilateral motor and visual regions. These AD-related differences in regional coactivation during motor execution may represent inefficiency in the motor network as a c...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
May 1, 1982·Journal of Gerontology·R I PfefferS Filos
Mar 1, 1996·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·M B DickM L Kean
Jan 1, 1997·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·A KlugerB Reisberg
Mar 1, 1997·Neuropsychologia·M A BellgroveH Hecht
May 1, 1997·Journal of the American Geriatrics Society·D B HowiesonJ A Kaye
May 1, 1997·NeuroImage·C J Price, K J Friston
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·D SuvàJ Miklossy
Jan 29, 2002·International Journal of Geriatric Psychiatry·Vince Salazar ThomasJane F Potter
Jul 12, 2002·Human Brain Mapping·Steven C CramerBruce R Rosen
Jan 2, 2003·Annals of Neurology·Florinda FerreriPaolo Maria Rossini
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Aug 11, 2004·Behavioral Neuroscience·Claudio BabiloniPaolo Maria Rossini
Feb 9, 2006·Brain Research Bulletin·Claudio BabiloniPaolo M Rossini
Jun 20, 2006·Journal of Neuropathology and Experimental Neurology·Ann C McKeePhilip A Wolf
Sep 26, 2006·Neurobiology of Aging·Anne HämäläinenHilkka Soininen
Jul 11, 2007·International Journal of Geriatric Psychiatry·Max ToepperMartin Driessen
Aug 30, 2007·Behavioural Neurology·Rosolino CamardaMassimo Gangitano
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sarah E MacPhersonGordon K Wilcock
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christian SorgAfra M Wohlschläger
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer's Association
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yongxia ZhouR Kent Hutson
Aug 13, 2008·Archives of Neurology·Sid E O'BryantUNKNOWN Texas Alzheimer's Research Consortium
Jan 28, 2009·Human Brain Mapping·Birgit KeiskerSpyros S Kollias
Mar 12, 2009·Human Brain Mapping·Christine Fennema-NotestineUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 23, 2009·Journal of Neurology·Reiner KaschelSergio Della Sala
Sep 15, 2009·Current Alzheimer Research·Christian SorgAfra M Wohlschläger
Sep 25, 2009·Human Brain Mapping·Federica AgostaMassimo Filippi

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Citations

May 21, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mariagiovanna CantoneVincenzo Di Lazzaro
Mar 24, 2016·Journal of X-ray Science and Technology·Zhiqun WangKuncheng Li
Sep 9, 2015·Frontiers in Aging Neuroscience·Chun Liang HsuTeresa Liu-Ambrose
Nov 11, 2014·The Cerebellum·Leonardo BaldarçaraChristophe Habas
Apr 6, 2020·Aging·Weimin ZhengUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 19, 2018·Journal of Neurology·Avinash ChandraUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 17, 2013·Gerodontology·Fanny ElsigFrauke Müller
Apr 27, 2018·Frontiers in Aging Neuroscience·Xingyun LiuZhiqun Wang
Jun 1, 2017·Frontiers in Aging Neuroscience·Weimin ZhengZhiqun Wang
Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Magdalena I ToleaJames E Galvin
Dec 30, 2021·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Shayne S-H Lin, Ian M McDonough

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