Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
S M O'MahonyTimothy G Dinan

Abstract

Efforts to define either a biomarker for irritable bowel syndrome (IBS) or a valid animal model have proven disappointing. The aims of this study were to determine if buspirone stimulates prolactin release through the 5-hydroxytryptamine (5HT)1a receptor and whether this response is altered in patients with IBS and in the rat maternal separation model. Buspirone (30 mg) was used to stimulate prolactin release in 40 patients with IBS and in 40 healthy controls. In study 1, 10 IBS patients and 10 controls underwent pretreatment with pindolol (5HT1a antagonist) or placebo followed by buspirone. In study 2, 30 patients with IBS and 30 healthy controls had prolactin release stimulated by buspirone. Maternally separated and nonseparated rats were also treated with buspirone and prolactin monitored. Serotonin metabolites were measured together with the expression of the 5HT1a and serotonin transporter (SERT) gene. Pindolol produced a dose-dependent decrease in the buspirone prolactin response. Patients with IBS and maternally separated rats showed an exaggerated release of prolactin in response to buspirone. In the animal model, an increased turnover of 5HT was found in the brainstem together with a trend toward increased activity of ...Continue Reading

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Citations

Oct 5, 2010·Psychopharmacology·Siobhain M O'MahonyJohn F Cryan
Jan 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael Camilleri
Mar 27, 2012·PloS One·Harriët SchellekensJohn F Cryan
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Nov 30, 2010·Pharmacology, Biochemistry, and Behavior·Cliona M O'MahonyJohn F Cryan
May 25, 2010·Neuroscience Letters·Ricardo LlorenteMaría-Paz Viveros
Oct 9, 2009·Trends in Molecular Medicine·Gerard ClarkeTimothy G Dinan
Dec 17, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S M O'MahonyJ F Cryan
Jan 28, 2014·Neuropharmacology·Osnat MelamedHava M Golan
Feb 24, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A P S HunginN J De Wit
May 13, 2015·Psychoneuroendocrinology·Matteo M PuscedduTimothy G Dinan
Mar 26, 2013·Brain Research Bulletin·Xiaofang XueWeiwen Wang
Jul 23, 2011·Neuroscience and Biobehavioral Reviews·Paul J KennedyJohn F Cryan
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Jun 30, 2019·The Proceedings of the Nutrition Society·Marion Rincel, Muriel Darnaudéry
Aug 31, 2011·Stress : the International Journal on the Biology of Stress·Marcela Julio-PieperJohn F Cryan
Feb 14, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Lars WilmesGerard Clarke
Feb 2, 2021·The FEBS Journal·Praachi TiwariVidita A Vaidya
Aug 20, 2021·Neurobiology of Pain·David BrennerSiobhain M O'Mahony

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