PMID: 6969064Aug 1, 1980Paper

Evidence of an immediate hypersensitivity mechanism in systemic lupus erythematosus

Annals of the Rheumatic Diseases
J EgidoL Hernando

Abstract

In 30 patients with systemic lupus erythematosus the number of a circulating basophils was countered in different stages of activity. An inverse correlation was found between the absolute basophils count and anti-DNA antibodies and presumptive circulating immune complexes (as judged by polyethylene glycol precipitation of serum). A positive correlation was found between the absolute basophil count and C3 or C4 levels. IgE on the basophil surface was determined by radioimmunoassay in 7 patients. All of them showed a significantly higher surface IgE number. When the count of circulating basophils was roughly normal, 5 out of the 6 patients showed a positive basophil degranulation test with native DNA. These results suggest the existence of an anti-DNA specific IgE in lupus patients. Depression of the circulating basophil count may be a useful index of lupus activity.

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Citations

Oct 1, 1989·The Journal of Allergy and Clinical Immunology·L GaloppinC Burtin
Feb 13, 1982·Lancet·E PirotzkyC Noirot
Nov 19, 2014·Clinical Rheumatology·Peifen LiangAnping Xu
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G MaroneG Condorelli
May 15, 2007·Immunological Reviews·Ulrich BlankYutaka Kanamaru
Apr 23, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicolas CharlesEric Daugas
Oct 11, 2017·Clinical Rheumatology·Peifen LiangAnping Xu
Aug 1, 1981·European Journal of Immunology·Y de KozakJ P Faure
Aug 3, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Zaixing YangYan Liang
Dec 12, 2020·Antibodies·Yasmine Lamri, Nicolas Charles

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