Evidence of astrogliosis in rat hippocampus after d-amphetamine exposure

Progress in Neuro-psychopharmacology & Biological Psychiatry
Benício N FreyFlávio Kapczinski

Abstract

Psychostimulants such as amphetamine (AMPH) induce manic-like symptoms in humans and studies have suggested that bipolar disorder (BD) may be associated to dopamine dysfunction. Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization. We aimed to investigate the behavioral effects of acute and chronic AMPH on rat locomotion and assess GFAP levels in rat cortex and hippocampus. Rats were administered either acute (single dose) or chronic (seven days) d-amphetamine IP injection. Locomotion was assessed with an open-field test and GFAP immunoquantity was measured using ELISA. Chronic, but not acute, administration of AMPH increased GFAP levels in rat hippocampus. No differences were observed in rat cortex. Repeated exposure to AMPH leads to an astroglial response in the hippocampus of rats.

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Citations

May 15, 2008·Psychopharmacology·Suzanne C Wood, Stephan G Anagnostaras
Sep 13, 2013·Journal of Child and Adolescent Psychopharmacology·Nathalie BockTill Manzke
Nov 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christina H LiuPhilip K Liu
Dec 17, 2014·Molecular Neurobiology·Carolina GubertAna Maria Oliveira Battastini
Oct 11, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ronald KimKathryn J Reissner

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