Evidence of cellular senescence during the development of estrogen-induced pituitary tumors

Endocrine-related Cancer
Maria Eugenia SabatinoAna Lucía De Paul

Abstract

Although pituitary adenomas represent 25% of intracranial tumors, they are usually benign, with the mechanisms by which these tumors usually avoid an invasive profile and metastatic growth development still remaining unclear. In this context, cellular senescence might constitute a plausible explanation for the benign nature of pituitary adenomas. In this study, we investigated the emergence of cellular senescence as a growth control mechanism during the progression of estrogen-induced pituitary tumors. The quantification of Ki67-immunopositive cells in the pituitaries of estrogenized male rats after 10, 20, 40, and 60 days revealed that the mitogenic potential rate was not sustained for the whole period analyzed and successively decreased after 10 days of estrogen exposure. In addition, the expression of cellular senescence features, such as the progressive rise in the enzymatic senescence-associated b-galactosidase (SA-b-gal) activity, IL6, IL1b, and TGFb expression, was observed throughout pituitary tumor development. Furthermore, tumoral pituitary cells also displayed nuclear pATM expression, indicating activated DNA damage signaling, with a significant increase in p21 expression also being detected. The associations among D...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Nov 1, 1996·The Biochemical Journal·N L Weigel
Aug 1, 1997·Molecular and Cellular Biology·V V OgryzkoB H Howard
Feb 2, 1999·Experimental Cell Research·A L Gartel, A L Tyner
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jun 1, 2000·Experimental Gerontology·F Bringold, M Serrano
Sep 26, 2000·Molecular and Cellular Biology·K E KnudsenE S Knudsen
Nov 18, 2000·Pituitary·A M McNicol, E Carbajo-Perez
May 19, 2001·European Journal of Biochemistry·K ItahanaJ Campisi
Oct 25, 2001·Cancer Letters·O Pluquet, P Hainaut
Oct 31, 2001·Trends in Cell Biology·J Campisi
Nov 8, 2001·Current Opinion in Cell Biology·M Serrano, M A Blasco
Nov 29, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W BaschongR H Laeng
Aug 15, 2002·The Journal of Endocrinology·A Levy
Nov 5, 2002·Nature Reviews. Cancer·Sylvia L Asa, Shereen Ezzat
Aug 13, 2003·The EMBO Journal·Christian M BeauséjourJudith Campisi
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Nov 16, 2004·Mechanisms of Ageing and Development·Richard MarcotteEugenia Wang
Nov 19, 2004·Nature·Scott W LoweGerard Evan
Aug 5, 2005·Nature·Manuel ColladoManuel Serrano
Aug 5, 2005·Nature·Melanie BraigClemens A Schmitt
Aug 5, 2005·Nature·Chrysiis MichaloglouDaniel S Peeper
Aug 6, 2005·Science·Judith Campisi
Jan 18, 2006·Pituitary·Antonio CiccarelliAlbert Beckers
Feb 14, 2006·The Journal of Biological Chemistry·Wensheng LiuGokul M Das
Mar 15, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eli Pikarsky, Yinon Ben-Neriah
Apr 22, 2006·Aging Cell·Bo Yun LeeEun Seong Hwang
Jul 1, 2006·Frontiers of Hormone Research·Dipak K Sarkar
Sep 8, 2006·The New England Journal of Medicine·W J Mooi, D S Peeper
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gong YangJinsong Liu
Dec 1, 2006·Nature·Raffaella Di MiccoFabrizio d'Adda di Fagagna
Dec 13, 2006·Cancer Cell·Stéphanie Courtois-CoxKaren Cichowski
May 15, 2007·Oncogene·M M McKay, D K Morrison
Jun 5, 2007·The Journal of Biological Chemistry·Seungmin LeeHyeseong Cho

❮ Previous
Next ❯

Citations

Nov 18, 2015·Endocrine Pathology·Emilija Manojlovic-GacicOlivera Casar-Borota
Oct 25, 2016·Toxicology and Applied Pharmacology·Karen E Weis, Lori T Raetzman
Dec 12, 2019·Frontiers in Cell and Developmental Biology·Maria Eugenia SabatinoJose Luis Bocco
May 22, 2021·Cellular and Molecular Life Sciences : CMLS·Jose Mario Gonzalez-Meljem, Juan Pedro Martinez-Barbera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Frontiers of Hormone Research
Vera ChesnokovaShlomo Melmed
Molecular and Cellular Endocrinology
Vera Chesnokova, Shlomo Melmed
Biochemical and Biophysical Research Communications
Anastasia-Evi HandayaningsihYutaka Takahashi
© 2021 Meta ULC. All rights reserved