Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants

Gastroenterology
Sandy FengAlberto Sanchez-Fueyo

Abstract

A substantial proportion of pediatric liver transplant recipients develop subclinical chronic allograft injury. We studied whether there are distinct patterns of injury based on histopathologic features and identified associated immunologic profiles. We conducted a cross-sectional study of 157 stable, long-term pediatric recipients of transplanted livers (70 boys; > 6 years old at time of transplantation; mean, 8.9 ± 3.46 years after liver transplantation) who underwent liver biopsy analysis from August 13, 2012, through May 1, 2014. Participants had received livers from a living or deceased donor and had consistently normal results from liver tests. Liver biopsy specimens were scored by a central pathologist; an unsupervised hierarchical cluster analysis of histologic features was used to sort biopsy samples into 3 clusters. We conducted transcriptional and cytometric analyses of liver tissue samples and performed a systems biology analysis that incorporated clinical, serologic, histologic, and transcriptional data. The mean level of alanine aminotransferase in participants was 27.6 ± 14.57 U/L, and the mean level of γ-glutamyl transferase was 17.4 ± 7.93 U/L. Cluster 1 was characterized by interface activity (n = 34), cluster...Continue Reading

References

Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Feb 13, 2003·Nucleic Acids Research·Rafael A IrizarryTerence P Speed
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Helen M EvansStefan Hübscher
May 2, 2006·The Journal of Pediatrics·Kathleen M CampbellJohn C Bucuvalas
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Megan L TroxellNeeraja Kambham
May 24, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Wing-Kin SynJames M Neuberger
Jul 5, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K A SoltysUNKNOWN SPLIT Research Group
Aug 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marie LaryeaKevork M Peltekian
Dec 29, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R W ShepherdUNKNOWN SPLIT Research Group
Jan 9, 2008·Pediatric Transplantation·Eba HathoutUNKNOWN SPLIT study group
Jun 27, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Denise HerzogFernando Alvarez
Nov 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Udeme D EkongEstella M Alonso
Dec 23, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rene ScheenstraAnnette S H Gouw
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Apr 24, 2010·The New England Journal of Medicine·Michael X PhamUNKNOWN IMAGE Study Group
Dec 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrea M Burns, Anita S Chong
Jun 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyP I Terasaki
Oct 14, 2011·Journal of Translational Medicine·Tara L SpiveyDavide Bedognetti
Dec 24, 2011·The Journal of Pediatrics·Vicky L NgUNKNOWN Studies of Pediatric Liver Transplantation (SPLIT) Research Group
Mar 2, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ananya PongpaibulCharles R Lassman
Mar 21, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Apr 18, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hugo KanekuGöran B Klintmalm
May 31, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·UNKNOWN Banff Working Group on Liver Allograft Pathology
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C VenturiR Reding
Aug 14, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Aya Miyagawa-HayashinoHironori Haga
Nov 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kumiko IsseAnthony J Demetris
Mar 28, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlos BenítezAlberto Sánchez-Fueyo
Jul 10, 2013·Pediatric Transplantation·Andrea Briem-RichterEnke Grabhorn
Sep 27, 2013·The New England Journal of Medicine·Alexandre LoupyXavier Jouven
Jan 29, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Timucin TanerJulie K Heimbach
Mar 4, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyG B Klintmalm
Jun 18, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C VenturiR Reding
Mar 17, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyP I Terasaki
Oct 31, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E Bonaccorsi-RianiA Sánchez-Fueyo
Dec 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Haas
Jun 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J DemetrisY Zen
Jun 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandy FengNadia K Tchao
Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deirdre KellyStefan Hübscher

❮ Previous
Next ❯

Citations

Jan 8, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Emily R PeritoSandy Feng
Jul 26, 2019·Pediatric Transplantation·Vicky Lee NgJohn C Bucuvalas
Sep 29, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Annette M JacksonSandy Feng
Jan 21, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sharad I WadhwaniJennifer C Lai
Feb 16, 2019·Transplantation·Michelle A Wood-TrageserAnthony J Demetris
Nov 14, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josh LevitskyJames M Mathew
Apr 22, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rie IrieMureo Kasahara
Jun 12, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elliot MerrittMarc Martínez-Llordella
Jun 13, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fadi IssaAngus W Thomson
May 20, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael MengelRobert B Colvin
May 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Josh LevitskyUNKNOWN Clinical Trials in Organ Transplantation - 14 Consortium
May 21, 2020·Journal of Neural Engineering·Christi L KolarcikX Tracy Cui
Feb 25, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Katelynn Madill-ThomsenPhilip F Halloran
Aug 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Angus W ThomsonAlberto Sanchez-Fueyo
Mar 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alton B FarrisKim Solez
Jul 17, 2020·Frontiers in Immunology·Xiaoxiao DuZhonghua Klaus Chen
Sep 27, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·George V MazariegosMiguel Reyes-Mugica
Dec 6, 2020·Current Opinion in Organ Transplantation·Stela Celaj, Josh Levitsky
Aug 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Naire SansottaLorenzo D'Antiga
Dec 8, 2019·Gastroenterología y hepatología·Julien VionnetJordi Colmenero
Feb 17, 2021·Pediatric Transplantation·Alvin P ChanLaura J Wozniak
Mar 7, 2021·International Journal of Molecular Sciences·Filip CvetkovskiErik Berglund
Dec 24, 2018·Journal of Hepatology·François DurandClaire Francoz
Aug 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Emma Monique SaelensRuth M L De Bruyne
Mar 16, 2021·Journal of Pediatric Gastroenterology and Nutrition·Kathryn Smith, Emily R Perito
Aug 14, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandy FengAnthony J Demetris
Apr 29, 2021·Journal of Pediatric Gastroenterology and Nutrition·Juliane K GötzUlrich Baumann
Jun 22, 2021·The Journal of Pediatrics·Caroline B EwingJames E Squires
Jul 23, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cristina M Farkas-SkilesPatricia L Weng
Jun 25, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roberta AngelicoPaola Francalanci
Aug 15, 2021·Military Medical Research·Ying WangKonrad Fischer
Aug 27, 2021·Journal of Hepatology·Julien VionnetAlberto Sánchez-Fueyo
Aug 30, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Emily A SaundersRichard Taubert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Udeme D EkongEstella M Alonso
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
C WiebeP W Nickerson
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Andrew TranBibhuti B Das
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
P G DeanMark D Stegall
© 2022 Meta ULC. All rights reserved