PMID: 8964525Apr 1, 1996Paper

Evidence of chronic inflammation in retina excised after relaxing retinotomy for anterior proliferative vitreoretinopathy

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
G A LimbD C Dumonde

Abstract

Epiretinal membranes from eyes with proliferative vitreoretinopathy (PVR) frequently express molecules associated with chronic inflammation. To investigate the extent to which inflammation may compromise the detached retina, we determined the expression of inflammatory molecules in anterior retina removed after relaxing retinotomy for retinal detachment complicated by anterior PVR. Surgical retinal specimens were studied immunohistochemically for the distribution of the vascular cell adhesion molecules VCAM, E-selectin, P-selectin, ICAM and PECAM and for the presence of the cytokine TNF alpha and of T lymphocytes (CD3-positive cells), macrophages (CD68-positive cells) and HLA-DR molecules. The findings were compared with those in control cadaveric retina. Aberrant expression of ICAM-1 was observed in four of nine retinal specimens from eyes with PVR, whereas its expression in control retinas was confined to the external limiting membrane and ganglion cell layers. PECAM was observed in seven of nine surgical retinal specimens and in four of five controls. E-selectin and P-selectin were expressed within the luminal aspects of four of nine retinal specimens from eyes with PVR, and VCAM was present in three of nine surgical specime...Continue Reading

References

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H P Heidenkummer, A Kampik
Sep 1, 1992·Ophthalmology·D G CharterisS L Lightman
Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·D B ChandlerR Machemer
Nov 15, 1991·European Journal of Biochemistry·G CamussiF Bussolino
Mar 1, 1991·Respiratory Medicine·S Montefort, S T Holgate
Jan 1, 1991·Eye·G A LimbD C Dumonde
Aug 15, 1991·American Journal of Ophthalmology·R MachemerR M Michels
Jan 1, 1991·The British Journal of Ophthalmology·P Hiscott, I Grierson
Nov 1, 1989·Immunology Today·A Mantovani, E Dejana
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Nov 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G A LimbD C Dumonde
Jun 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G A LimbD C Dumonde
Jan 1, 1993·American Journal of Ophthalmology·S J Ryan
Feb 1, 1993·Arthritis and Rheumatism·B N Cronstein, G Weissmann
Mar 1, 1993·Immunology Today·C R Mackay, B A Imhof

❮ Previous
Next ❯

Citations

Nov 30, 2002·Experimental Eye Research·M Valeria Cantó SolerAngela M Suburo
Aug 28, 2016·The British Journal of Ophthalmology·Petros PetrouDavid G Charteris
Aug 25, 2020·Translational Vision Science & Technology·Alison HefferAjay E Kuriyan
Oct 23, 1997·Current Eye Research·G A LimbM R Stanford
Nov 3, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah A B WhitmoreLeo A Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
C A WilsonR Machemer
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Sandrine FlorquinJan J Weening
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
V G NicolettiA Reibaldi
© 2021 Meta ULC. All rights reserved