Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity?

Archives of Ophthalmology
Sunali GoyalReza Dana

Abstract

To determine the effect of desiccating stress on corneal angiogenic responses in dry eye disease (DED) using a murine model. Dry eye was induced in murine eyes using high-flow desiccated air. Corneas were double stained with CD31 (panendothelial marker) and LYVE-1 (lymphatic endothelial marker). Real-time polymerase chain reaction was performed to quantify expression of vascular endothelial growth factors (VEGF-A, VEGF-C, and VEGF-D) and their receptors (VEGFR-2 and VEGFR-3) in the cornea on days 6, 10, and 14. Enumeration of CD11b(+)/LYVE-1(+) monocytic cells was performed in corneas with DED on day 14. Flow cytometric evaluation of the draining lymph nodes in normal mice and mice with DED was performed to determine whether DED is associated with homing of mature (major histocompatibility complex class II(hi)) antigen-presenting cells to the lymphoid compartment. Lymphatic vessels unaccompanied by blood vessels were seen growing toward the center of corneas with DED. Significant increases in lymphatic area (P < .001) and lymphatic caliber (P < .02) were seen on day 14 of disease. Lymphangiogenic-specific VEGF-D and VEGFR-3 levels increased earliest on day 6 followed by increased VEGF-C, VEGF-A, and VEGFR-2 levels. Increased re...Continue Reading

References

May 4, 2000·The American Journal of Pathology·K PaavonenK Alitalo
Jul 31, 2003·American Journal of Ophthalmology·Debra A SchaumbergM Reza Dana
Apr 2, 2004·The Journal of Clinical Investigation·Claus CursiefenJ Wayne Streilein
Jul 28, 2004·Investigative Ophthalmology & Visual Science·Claus CursiefenJ Wayne Streilein
Jul 27, 2005·Investigative Ophthalmology & Visual Science·Stefano BarabinoM Reza Dana
Sep 3, 2005·The Journal of Clinical Investigation·Dontscho Kerjaschki
Sep 3, 2005·The Journal of Clinical Investigation·Kazuichi MaruyamaJ Wayne Streilein
Oct 20, 2006·Nature·Balamurali K AmbatiJayakrishna Ambati
Feb 1, 2007·Chemical Immunology and Allergy·Claus Cursiefen
Apr 27, 2007·Investigative Ophthalmology & Visual Science·Heping XuJohn V Forrester
Aug 28, 2007·Cell·Hanna Heloterä, Kari Alitalo
Aug 28, 2007·Thrombosis and Haemostasis·Ruediger Liersch, Michael Detmar
Feb 13, 2008·Archives of Ophthalmology·Saadia RashidM Reza Dana
Dec 10, 2008·Archives of Ophthalmology·Tatiana EcoiffierReza Dana
Apr 3, 2009·Investigative Ophthalmology & Visual Science·Jaafar El AnnanReza Dana
Jun 18, 2009·Mucosal Immunology·S K Chauhan, R Dana
Jul 15, 2009·Immunological Reviews·David G Jackson

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Citations

Apr 24, 2012·Journal of Ophthalmology·Tatiana EcoiffierLu Chen
Sep 14, 2011·Archives of Ophthalmology·Sunali GoyalReza Dana
Jan 11, 2012·Archives of Ophthalmology·William StevensonReza Dana
Apr 24, 2012·Journal of Ophthalmology·Shintaro NakaoTatsuro Ishibashi
Dec 24, 2014·Ocular Immunology and Inflammation·Marjan FaridLbachir BenMohamed
Jul 15, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Laura SchöllhornClaus Cursiefen
Jan 31, 2013·International Reviews of Immunology·Michael E SternStephen C Pflugfelder
Jan 26, 2013·Progress in Retinal and Eye Research·Felix BockClaus Cursiefen
Sep 13, 2011·Blood·Sunil K ChauhanReza Dana
Mar 20, 2012·Progress in Retinal and Eye Research·Stefano BarabinoReza Dana
May 1, 2012·American Journal of Ophthalmology·Andre OkanoboReza Dana
Jul 1, 2017·International Journal of Molecular Sciences·Xiaobo ZhangWei Li
Mar 13, 2018·Medicinal Research Reviews·Michael YamakawaDimitri T Azar
Jan 11, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Kalaivarny GanesalingamJennifer P Craig
Mar 22, 2019·Investigative Ophthalmology & Visual Science·Mingxia SunVivien J Coulson-Thomas
Oct 13, 2017·Cornea·Takenori InomataReza Dana
Feb 15, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Basilio ColligrisJesus Pintor
Dec 24, 2015·Military Medical Research·Pedro CuevasGuillermo Giménez-Gallego
May 6, 2016·The British Journal of Ophthalmology·Giulio FerrariRoberta Mazzieri
Sep 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris S SchaumburgMichael E Stern
Feb 29, 2020·International Ophthalmology·Dimitrios KalogeropoulosChris Kalogeropoulos
Jun 27, 2019·Investigative Ophthalmology & Visual Science·Ying LiKyung Chul Yoon
Oct 27, 2020·Cutaneous and Ocular Toxicology·Hui LiPeirong Lu
May 30, 2020·The Ocular Surface·Nai-Wen FanReza Dana
Feb 17, 2015·Deutsches Ärzteblatt International·Elisabeth M Messmer
Dec 10, 2020·International Journal of Molecular Sciences·Kazuo TsubotaReza Dana
Oct 30, 2020·Translational Vision Science & Technology·Viet Nhat Hung LeClaus Cursiefen
Sep 6, 2020·The Ocular Surface·Cameron K PostnikoffKelly K Nichols
Apr 4, 2021·International Journal of Molecular Sciences·Jamie D KraftEmma Börgeson
Apr 4, 2021·Survey of Ophthalmology·Mohansrinivas ChennakesavaluDimitri T Azar
Jul 3, 2021·International Journal of Molecular Sciences·Uta GehlsenPhilipp Steven

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