Evidence of Cyclic Changes in the Metabolism of Abdominal Aortic Aneurysms During Growth Phases: ¹⁸F-FDG PET Sequential Observational Study

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Olivier MorelPierre-Yves Marie

Abstract

The rates of growth of medically treated abdominal aortic aneurysms (AAA) are difficult to determine, and relationships with parietal inflammation and with metabolic parameters from (18)F-FDG PET remain unclear. This (18)F-FDG PET sequential observational study was aimed at analyzing the metabolic changes accompanying the growth phases of medically treated AAA. Thirty-nine patients (37 men; age [mean ± SD], 71 ± 12 y) exhibiting small and medically treated AAA (maximal diameter, 46 ± 3 mm) underwent (18)F-FDG PET and CT angiography at baseline and 9 mo later. Clinical and imaging parameter correlates of the 9-mo increase in maximal diameter were investigated; these included (18)F-FDG maximal standardized uptake values (SUVmax) averaged for slices encompassing the AAA volume. Of the 39 patients, 9 (23%) had a significant (≥2.5 mm) increase in maximal diameter at 9 mo, whereas the remaining 30 did not. The patients with an increase in maximal diameter at 9 mo exhibited lower SUVmax within the AAA at baseline than patients who did not have such an increase (1.80 ± 0.45 vs. 2.21 ± 0.52; P = 0.04); they also displayed a trend toward greater changes in SUVmax at 9 mo (difference between 9 mo and baseline: +0.40 ± 0.85 vs. -0.06 ± 0.5...Continue Reading

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Citations

Jun 11, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H JalalzadehR Balm
Nov 4, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gang ChengAbass Alavi
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Jul 7, 2019·European Radiology·Bouke P AdriaansSimon Schalla
Feb 3, 2018·Nuclear Medicine and Molecular Imaging·Hyunjong LeeKeon Wook Kang
Nov 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Pierre-Yves MariePatrick Rossignol
Dec 22, 2020·Vascular and Endovascular Surgery·Martin RouerDidier Plissonnier
Mar 26, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael BellMarc A Bailey
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May 13, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Richa GandhiCharalampos Tsoumpas
Apr 25, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James H F RuddAshley M Groves
Jul 27, 2021·Frontiers in Medicine·Li YinZhenjie Liu

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