PMID: 8597676Feb 24, 1996Paper

Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years

BMJ : British Medical Journal
S IrvineJ Aitken

Abstract

To determine whether the quality of semen has changed in a group of over 500 Scottish men born between 1951 and 1973. Retrospective review of data on semen quality collected in a single laboratory over 11 years and according to World Health Organisation guidelines. Programme of gamete biology research funded by Medical Research Council. 577 volunteer semen donors. Of these, 171 were born before 1959, 120 were born in 1960-4, 171 in 1965-9, and 115 in 1970-4. Conventional criteria of semen quality including semen volume (ml), sperm concentration (10(6)/ml), overall motility (% motile), total number of sperm in the ejaculate (10(6)), and total number of motile sperm in the ejaculate (10(6)). When the four birth cohort groups were compared a later year of birth was associated with a lower sperm concentration, a lower total number of sperm in the ejaculate, and a lower number of motile sperm in the ejaculate. The median sperm concentration fell from 98x10(6)/ml among donors born before 1959 to 78x10(6)/ml among donors born after 1970 (P=0.002). The total number of sperm in the ejaculate fell from 301x10(6) to 214x10(6) (P=0.0005), and the total number of motile sperm in the ejaculate fell from 169.7x10(6) to 129.0x10(6) (P=0.0065)....Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Oct 1, 1992·International Journal of Andrology·A Giwercman, N E Skakkebaek
Jul 21, 1990·BMJ : British Medical Journal·A TempletonB Thompson
Jun 1, 1987·European Journal of Cancer & Clinical Oncology·P BoyleA G Robertson
Jun 1, 1974·Fertility and Sterility·C M Nelson, R G Bunge
Jan 1, 1984·Archives of Andrology·S OsserJ Ranstam
Feb 2, 1995·The New England Journal of Medicine·J AugerP Jouannet
Feb 2, 1995·The New England Journal of Medicine·R J Sherins
Jul 2, 1994·BMJ : British Medical Journal·P BromwichA Walker

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Citations

Jul 1, 1997·Journal of Assisted Reproduction and Genetics·A BenshushanA Lewin
Jul 13, 2005·International Archives of Occupational and Environmental Health·R Winker, H W Rüdiger
Dec 27, 2008·Bulletin of Experimental Biology and Medicine·T E Potemina
Jun 12, 2002·Contraception·Wu JunqingGao Ersheng
Feb 15, 2001·Fertility and Sterility·S A KiddA J Wyrobek
Mar 2, 2002·Fertility and Sterility·Wai Yee WongRégine P M Steegers-Theunissen
Jun 1, 1997·Fertility and Sterility·S Becker, K Berhane
Feb 26, 2000·Fertility and Sterility·W Y WongR P Steegers-Theunissen
Dec 31, 1997·The Science of the Total Environment·P T HarrisonC D Humfrey
Jun 5, 2003·Medical Hypotheses·Harry FischCarl A Olsson
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·A Giwercman, J P Bonde
Feb 27, 2001·Mutation Research·N O BianchiS M Richard
Nov 15, 2007·European Journal of Human Genetics : EJHG·Joan K MorrisPatricia Jacobs
Dec 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kim H BrownJames J Nagler
Jun 4, 2002·Human Reproduction·Tina Kold JensenNiels E Skakkebaek
Aug 18, 2009·Human Reproduction·S BhattacharyaJ J Kurinczuk
Nov 26, 2009·Human Reproduction·Michael Joffe
Jul 6, 2010·Human Reproduction·Benjamin N BreyerMichael L Eisenberg
Aug 14, 2012·Human Reproduction·Audrey J GaskinsJorge E Chavarro
Aug 19, 2008·Human Reproduction Update·Anders Nyboe AndersenAnne Loft
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Apr 3, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cendrine Geoffroy-SiraudinMarie-Roberte Guichaoua
Sep 22, 2000·Archives of Disease in Childhood·C J PartschW G Sippell
Feb 24, 1996·BMJ : British Medical Journal·D M de Kretser
Jun 22, 1996·BMJ : British Medical Journal·S Irvine
Jul 6, 1996·BMJ : British Medical Journal·A J Eccersley
Jul 6, 1996·BMJ : British Medical Journal·S Farrow
Feb 26, 1999·BMJ : British Medical Journal·H Møller, N E Skakkebaek
Sep 14, 2001·Occupational and Environmental Medicine·N CherryT Tulandi
Feb 9, 2012·Advances in Urology·Lidia Mínguez-AlarcónAlberto M Torres-Cantero
Jan 21, 2010·BMC Public Health·Hiltrud MerzenichMaria Blettner

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