PMID: 9541473Apr 16, 1998Paper

Evidence of ED-B+ fibronectin synthesis in human tissues by non-radioactive RNA in situ hybridization. Investigations on carcinoma (oral squamous cell and breast carcinoma), chronic inflammation (rheumatoid synovitis) and fibromatosis (Morbus Dupuytren)

Histochemistry and Cell Biology
Alexander BerndtH Kosmehl

Abstract

The splicing variant of fibronectin containing the ED-B domain (oncofoetal fibronectin) occurs in foetal tissues, reparative processes, organ fibrosis and in tumour tissues. Consequently, a supportive effect of ED-B+ fibronectin for tissue remodelling and tumour progression is assumed. A non-radioactive RNA-RNA in situ hybridization protocol for the investigation of ED-B+ fibronectin synthesis applicable in human tissues is introduced. The ED-B+ fibronectin synthesis was investigated in human disease processes, for which the occurrence of ED-B+ fibronectin is well demonstrated by immunohistochemistry (rheumatoid arthritis, oral squamous cell carcinoma, invasive ductal carcinoma of the breast and nodular palmar fibromatosis). The ED-B+ fibronectin synthesis could be shown in lining cells and in endothelial cells of synovial villi in rheumatoid arthritis, in stromal cells of oral squamous cell carcinoma and invasive ductal carcinoma and in fibro-/myofibroblasts in the proliferative and early involutional phase of nodular palmar fibromatosis. By means of double labelling (alpha-smooth muscle actin immunostaining - ED-B+ fibronectin in situ hybridization), the ED-B+ fibronectin synthesis could be shown to be a typical feature of my...Continue Reading

Citations

Jan 31, 2007·Arthritis Research & Therapy·Eveline TrachselDario Neri
Oct 26, 2012·The Journal of Investigative Dermatology·Kathrin SchwagerDario Neri
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Manuela KasparDario Neri
Dec 16, 2004·Oral Oncology·Paulette MhawechAbdelkarim S Allal
Mar 30, 2004·The Journal of Surgical Research·Jeffrey C HowardBing Siang Gan
Jul 11, 2006·Advanced Drug Delivery Reviews·Eveline Trachsel, Dario Neri
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Jan 31, 2003·Expert Opinion on Therapeutic Targets·Anna C Erickson, Mary Helen Barcellos-Hoff
Jan 20, 2017·Nature Communications·Sandeep GopalEllen Van Obberghen-Schilling
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Aug 23, 2003·Blood·Laura BorsiLuciano Zardi
Nov 21, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carla R ScanzelloYejia Zhang
Jan 26, 2021·Journal of Structural Biology·Tiziano OngaroFederico Forneris

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