Evidence of endothelial activation and endothelial activators in cord blood of infants of preeclamptic women

American Journal of Obstetrics and Gynecology
S T DavidgeJ M Roberts

Abstract

In preeclampsia markers of endothelial activation (e.g., increased cellular fibronectin and activities that alter in vitro endothelial function (e.g., stimulation of nitric oxide and prostacyclin generation) are increased in the maternal circulation. We tested preeclamptic infant blood for these markers and activities and correlated these findings with fetal growth. Plasma was obtained from 17 term nulliparcus preeclamptic and normal pregnant women and their infants and from 8 additional preeclamptic mother-baby pairs from earlier gestations. Plasma cellular fibronectin and production of nitric oxide and prostacyclin by cultured endothelial cells exposed to 2% plasma were measured. Cellular fibronectin was higher in maternal plasma of preeclamptic than nonpregnant women (6.1 +/- 0.29 vs 4.2 +/- 0.27 microgram/ml, p < 0.01), as were stimulated endothelial nitric oxide and prostacyclin production (nitric oxide 42.5 +/- 3.9 vs 26.9 +/- 2.3 nmol nitrite/microgram protein/24 hours, p < 0.05; prostacyclin 261.7 +/- 31.2 vs 151.9 +/- 18.7 pg prostaglandin F1 alpha/microgram protein/24 hours, p < 0.05). In the preeclamptic infants cellular fibronectin was also greater (3.3 +/- 0.15 vs 2.6 +/- 0.14 microgram/ml, p < 0.01), as was endoth...Continue Reading

References

Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D W BranchM D Mitchell
Dec 11, 1991·American Journal of Obstetrics and Gynecology·R N TaylorJ M Roberts
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Jan 1, 1969·Gynaecologia. International Monthly Review of Obstetrics and Gynecology. Revue Internationale Mensuelle D'obstétrique Et De Gynécologie. Monatsschrift Für Geburtshilfe Und Gynäkologie·C H McCartney
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Sep 1, 1995·American Journal of Obstetrics and Gynecology·F LyallI A Greer
Oct 1, 1994·American Journal of Obstetrics and Gynecology·S P SeligmanS B Abramson
May 1, 1993·American Journal of Obstetrics and Gynecology·C BertrandJ St-Louis

❮ Previous
Next ❯

Citations

Oct 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·L ImpeyC Redman
Feb 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·C GreenwoodP Doyle
Nov 30, 2005·European Journal of Clinical Investigation·T A MillsP N Baker
Jan 7, 2000·The American Journal of Pathology·A ManyY Zhou
Nov 19, 2013·American Journal of Reproductive Immunology : AJRI·Ebba SohlbergUlrika Holmlund
Aug 22, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A SteinbornM Kaufmann
Jul 4, 2006·American Journal of Obstetrics and Gynecology·Roberta B Ness, Baha M Sibai
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Kristin BraekkeAnne Cathrine Staff
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Xin WangBrian Trudinger
Dec 17, 1998·American Journal of Obstetrics and Gynecology·R W PowersJ M Roberts
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Shaila J MerchantSandra T Davidge
Oct 27, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yang GuYuping Wang
Feb 28, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·E BujoldY M Kim
Jul 27, 2006·The Journal of International Medical Research·A KafkasliR Laurini
Feb 26, 2004·Journal of the Society for Gynecologic Investigation·José Martínez-OrgadoMercedes Salaices
Jan 31, 2006·Journal of the Society for Gynecologic Investigation·Ralf DechendFriedrich C Luft
Apr 23, 2014·Hypertension·Rocio Muñoz-HernandezJuan M Melero-Martin
Mar 9, 2005·American Journal of Physiology. Renal Physiology·Dinesh M Shah
Mar 30, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vincenzo ZanardoPaolo Simioni
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·I NeriA Volpe
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Raouf A Khalil, Joey P Granger
Jun 14, 2002·Placenta·J M Roberts, K Y Lain
Mar 17, 2019·The Journal of Pediatrics·Prabha H Andraweera, Zohra S Lassi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.