Evidence of endothelial dysfunction in preeclampsia and risk of adverse pregnancy outcome

Reproductive Sciences
Robert W PowersJ M Roberts

Abstract

The purpose of this study is to investigate whether endothelial dysfunction, as assessed by elevated cellular fibronectin (cFN), in women with preeclampsia is associated with an increased risk of preterm and/or small-for-gestational-age (SGA) births. Maternal plasma cFN was measured by enzyme-linked immunosorbent assay in samples collected at admission to delivery in 605 normotensive women, 171 women with transient hypertension, and 187 women with preeclampsia. Logistic regression was used to estimate the risk for preterm delivery, SGA, or both. Elevated cFN in women with preeclampsia was associated with an increased risk of both preterm and SGA births (odds ratio, 3.0; confidence interval [CI], 1.0-8.7) compared with women with preeclampsia without elevated cFN. The risk of preterm birth was 14.7-fold higher (CI, 8.1-26.7) and the risk of SGA was 6.8-fold higher (CI, 3.5-13.1) in women with preeclampsia, hyperuricemia, and elevated cFN compared with normotensive women. Elevated cFN is prevalent among women with preeclampsia and identifies women at increased risk of preterm delivery and SGA.

References

Feb 1, 1990·American Journal of Obstetrics and Gynecology·C J Lockwood, J H Peters
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Apr 1, 1989·American Journal of Obstetrics and Gynecology·E P Frohlich
Feb 1, 1984·British Journal of Obstetrics and Gynaecology·T LindP R Philips
Mar 1, 1994·American Journal of Obstetrics and Gynecology·S A FriedmanJ M Roberts
Jan 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R AustgulenC W Redman
Apr 1, 1997·British Journal of Obstetrics and Gynaecology·S DjurovicK Berg
Jul 9, 1998·Seminars in Reproductive Endocrinology·J M Roberts
Jul 31, 1998·The New England Journal of Medicine·R L Goldenberg, D J Rouse
Dec 17, 1998·American Journal of Obstetrics and Gynecology·R W PowersJ M Roberts
May 18, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Roberts
Sep 16, 2000·Hypertension·A YoshidaH Kobayashi
Feb 13, 2001·Obstetrics and Gynecology·J ZhangJ M Roberts
Jul 4, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D IslamiP Bischof
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·R W PowersJ M Roberts
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·E OstlundK Bremme
Sep 19, 2002·American Journal of Obstetrics and Gynecology·María Eugenia ChavarríaAlejandro Reyes
Oct 16, 2004·Journal of Korean Medical Science·Shin-Young KimEun Hee Cho
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Jul 21, 2005·Annals of Epidemiology·Lisa M BodnarJames M Roberts
Jul 23, 2005·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Kristine Y LainJames M Roberts

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Citations

Jan 29, 2011·Nephrology·Annemarie Hennessy, Angela Makris
May 17, 2011·The Journal of Membrane Biology·Gloria RiquelmeCarolina Rodríguez
Sep 12, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Henry AdekolaTinnakorn Chaiworapongsa
Feb 2, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nabih I El KhoulyEman E Badr
Oct 20, 2015·Gynécologie, obstétrique & fertilité·P GuerbyA Negre-Salvayre
Nov 19, 2015·International Journal of Molecular Sciences·Sandra FoundsJames M Roberts
Dec 17, 2008·Placenta·J M Roberts, C A Hubel
Nov 14, 2014·PloS One·Chang ShuFei Ye
Jan 2, 2008·American Journal of Obstetrics and Gynecology·Shi Wu WenMark C Walker
Jan 30, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·A D Lane-CordovaE P Gunderson
Apr 2, 2014·Hypertension·Leslie MyattUNKNOWN Global Pregnancy CoLaboratory
Nov 14, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Torbjørn Moe EggebøThomas Scholbach
Feb 17, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Abbi D Lane-CordovaDavid R Jacobs
Nov 15, 2011·Journal of Hypertension·Fabio AngeliPaolo Verdecchia
Nov 20, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Emily W HarvilleOlli T Raitakari
May 23, 2009·Obstetrics and Gynecology·Jacob Alexander LykkeJens Langhoff-Roos
Feb 27, 2021·Journal of the American College of Cardiology·Malamo E CountourisJanet M Catov
Jun 3, 2021·International Journal of Molecular Sciences·Lars BrodowskiFrauke von Versen-Höynck
Jun 24, 2010·Journal of Proteome Research·Juha RasanenSrinivasa R Nagalla

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