Evidence of epistasis between interleukin 1 and selenoprotein-S with susceptibility to rheumatoid arthritis

Annals of the Rheumatic Diseases
I MarinouA G Wilson

Abstract

Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1beta and tumour necrosis factor (TNF). It was hypothesised that these variants could influence rheumatoid arthritis (RA) susceptibility and may interact with functional single nucleotide polymorphisms (SNPs) in the genes for IL1, IL6 and TNF. Genotyping was performed in 988 unrelated healthy controls and 965 patients with RA. Stratified analysis was used to test for interactions. Single gene effects and evidence of epistasis were investigated using the Mantel-Haenszel (M-H) test and the linkage disequilibrium (LD)-based statistic. No association of SELS -105 genotype and RA susceptibility was detected. Stratification of SELS -105 genotypes by IL1 -511 genotypes showed that the disease risk (comparing AA/GA to GG at the SELS -105 locus) in individuals with the GG/AG genotype at the IL1beta -511 locus was significantly lower than that in individuals having the AA genotype at the IL1beta -511 locus (odds ratio (OR): 0.9 and 2.3, respectively; p = 0.004 by M-H test). Significant epistasis was also detecte...Continue Reading

Citations

Apr 29, 2009·Cellular and Molecular Life Sciences : CMLS·M A Reeves, P R Hoffmann
Mar 17, 2011·Journal of Periodontology·Dirk ZiebolzRainer F Mausberg
Sep 28, 2014·Arthritis Research & Therapy·Aida Ferreiro-IglesiasAntonio Gonzalez
Jul 25, 2009·The Biochemical Journal·Frederick P BellingerMarla J Berry
May 18, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kent HartShanbeh Zienolddiny
Feb 27, 2010·Arthritis and Rheumatism·Nieves PerdigonesElena Urcelay
Aug 12, 2017·Cardiovascular Diabetology·Shan-Shan Yu, Jian-Ling Du
Nov 13, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Xiao-Xia LiJin-Xiao Gao

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