Evidence of epithelial-mesenchymal transition in canine prostate cancer metastasis

Research in Veterinary Science
Carlos Eduardo Fonseca-AlvesR Laufer-Amorim

Abstract

The epithelial-mesenchymal transition (EMT) is a fundamental event responsible for the invasiveness and metastasis of epithelial tumours. The EMT has been described in many human cancers, but there are few reports of this phenomenon in veterinary oncology. Due to the importance of this process, the current study evaluated mesenchymal and epithelial marker protein expression in prostate lesions from dogs. Our results indicate both a loss of E-cadherin and translocation of β-catenin from the membrane to the cytoplasm and nucleus in the tumour group. Vimentin expression in the tumour group was higher than in normal tissue. All of the metastases were positive for prostate-specific antigen, pan-cytokeratin and E-cadherin, although fewer positive cells were present than in the primary tumours. The immunohistochemical results showed a loss of epithelial markers and a gain of a mesenchymal marker among metastatic cells, suggesting that the EMT occurs during the metastatic process of canine prostate carcinoma.

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Citations

May 29, 2016·Research in Veterinary Science·Luis Gabriel Rivera-CalderónRenée Laufer-Amorim
Oct 13, 2016·BMC Veterinary Research·Cristian M Suárez-SantanaAntonio Fernández
Jun 13, 2018·PloS One·Carlos Eduardo Fonseca-AlvesRenée Laufer-Amorim
Jun 25, 2020·Veterinary Pathology·Serenella SilvestriChiara Brachelente
Dec 19, 2019·Frontiers in Genetics·Carlos Eduardo Fonseca-AlvesRenee Laufer-Amorim
Jul 19, 2020·Nature Communications·Tae-Min KimSangwoo Kim
Mar 31, 2019·International Journal of Molecular Sciences·Renée Laufer-AmorimSilvia Regina Rogatto
Dec 7, 2017·BMC Veterinary Research·Carlos Eduardo Fonseca-AlvesRenée Laufer-Amorim
Apr 13, 2020·Research in Veterinary Science·Emerson Soares VelosoEnio Ferreira
May 1, 2021·Cancers·Giovana de Godoy FernandesCarlos Eduardo Fonseca-Alves
Jul 9, 2021·The Journal of Veterinary Medical Science·Yu FurusawaAkira Yabuki
Oct 18, 2021·Veterinary and Comparative Oncology·Takuro IshikawaKatsuhiko Warita

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