Evidence of functional vitamin D receptors in rat hippocampus

Neuroscience
M C LangubN J Koszewski

Abstract

The steroid hormone vitamin D has important biological roles in calcium transport, cell growth, and cell differentiation. Its cellular activities are mediated by high affinity interaction with the vitamin D receptor. In brain, autoradiographic, immunohistologic, and messenger RNA expression studies implicate a number of neuronal systems, including the hippocampus, as potential targets of vitamin D. However, cellular distribution and protein expression, and binding of the receptor to vitamin D response elements have yet to be established in hippocampus. This investigation was undertaken to characterize the vitamin D receptor in rat hippocampus with western blot, immunocytochemistry, and gel shift analyses. The presence of the receptor protein in hippocampus extracts was revealed with western blotting using an anti-rat vitamin D receptor antiserum. In vivo and in vitro immunocytochemical results confirmed the presence of vitamin D receptor in neuronal and glial cells. In the hippocampus, the receptor was localized in pyramidal and granule cell layers, CA1, CA2, and CA3 subfields and in the dentate gyrus. Double labeling for the vitamin D receptor and glial fibrillary acidic protein revealed that glia also expressed the receptor p...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T K RossH F DeLuca
Nov 1, 1991·Molecular Endocrinology·T SoneJ W Pike
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·W E Stumpf, T H Privette
Jan 1, 1991·Journal of Neuroscience Research·D WionP Brachet
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M B DemayH M Kronenberg
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J LiaoJ W Pike
Jan 1, 1987·Histochemistry·W E Stumpf, L P O'Brien
Jan 1, 1986·Annual Review of Nutrition·M R Haussler
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1986·Seminars in Nephrology
Dec 13, 1993·Neuroreport·P NaveilhanD Wion
Jan 1, 1994·Vitamins and Hormones·T K RossH F DeLuca
Jul 1, 1994·Brain Research. Molecular Brain Research·I NeveuP Brachet
Jun 1, 1994·Journal of Neuroscience Research·I NeveuM Garabédian
Oct 1, 1993·Experimental Neurology·M S SaporitoS Carswell
Apr 1, 1993·Brain Research. Molecular Brain Research·M K SutherlandD R McLachlan
Dec 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·N J KoszewskiR L Horst
Feb 4, 1998·Archives of Biochemistry and Biophysics·N J KoszewskiR L Horst
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Jan 8, 1999·Neurobiology of Aging·P W Landfield, L Cadwallader-Neal
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N J KoszewskiR L Horst

❮ Previous
Next ❯

Citations

Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Suzan OzerA Nurten Akarsu
Sep 29, 2001·Trends in Neurosciences·J McGrathA Mackay-Sim
Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Emmanuel GarcionDidier Wion
Nov 7, 2008·Journal of Neurotrauma·Jean-François ChabasFrançois Feron
May 29, 2004·Neuroreport·Allan V KalueffPentti Tuohimaa
Jun 7, 2013·PloS One·Jean-Francois ChabasFrancois Feron
Jun 27, 2007·The Tohoku Journal of Experimental Medicine·Duygu Gezen-AkSelma Yilmazer
Apr 9, 2014·BioMed Research International·Branka MarkovićNataša Petronijević
Oct 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Caitlin S LatimerNada M Porter
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Allan V Kalueff, Pentti Tuohimaa
Jun 2, 2012·Journal of Chiropractic Medicine·Ralph A Kruse, Jerrilyn A Cambron
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Lauren R HarmsJohn J McGrath
Jun 27, 2008·Molecular Aspects of Medicine·Jennifer S Buell, Bess Dawson-Hughes
Aug 24, 2007·Neurobiology of Aging·Maris KuningasDiana van Heemst
May 1, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Tiina KeisalaPentti Tuohimaa
May 8, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Anna MinasyanPentti Tuohimaa
Oct 16, 2015·Frontiers in Molecular Neuroscience·Anne L Lardner
Dec 23, 2003·Journal of the American Geriatrics Society·Leon FlickerJohn D Wark
Jan 16, 2010·Molecular Nutrition & Food Research·David Benton
Mar 22, 2016·Journal of Affective Disorders·Olivia I Okereke, Ankura Singh
Mar 19, 2014·Journal of the American Geriatrics Society·Valerie K WilsonUNKNOWN Health, Aging and Body Composition Study
Jul 28, 2004·Brain Research Bulletin·Allan V KalueffPentti Tuohimaa
Dec 13, 2005·Journal of Neurochemistry·Darja ObradovicTheo Rein
Nov 13, 2014·Monographs of the Society for Research in Child Development·Naiman A KhanCharles H Hillman
Sep 10, 2015·International Journal of Alzheimer's Disease·Anindita BanerjeeSasanka Chakrabarti
Jul 15, 2015·Psychiatry Research·Venkataram ShivakumarBangalore N Gangadhar
Oct 30, 2012·The Journal of Steroid Biochemistry and Molecular Biology·N M IdrusJ D Thomas
Apr 4, 2012·Nutrition·Brian C Clark, Todd M Manini
Jun 28, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Theresa Katharina SchäferThomas Meyer
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Anna MinasyanPentti Tuohimaa
Mar 10, 2004·International Review of Neurobiology·Alan Mackay-SimJohn McGrath
Jan 4, 2017·Muscle & Nerve·Sabrina PaganoniAnne-Marie Wills
Dec 2, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Consuelo H WilkinsJohn C Morris
Aug 4, 2005·Journal of Neurogenetics·Allan V KalueffPentti Tuohimaa
Oct 25, 2012·The Australian and New Zealand Journal of Psychiatry·Nayereh KhoraminyaAbolghassem Djazayery
Jan 11, 2018·Molecular Neurobiology·Maria MorelloPascal Millet

❮ Previous
Next ❯

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