Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate.

Human Genetics
Tao WuTerri H Beaty

Abstract

Although multiple genes have been identified as genetic risk factors for isolated, non-syndromic cleft lip with/without cleft palate (CL/P), a complex and heterogeneous birth defect, interferon regulatory factor 6 gene (IRF6) is one of the best documented genetic risk factors. In this study, we tested for association between markers in IRF6 and CL/P in 326 Chinese case-parent trios, considering gene-environment interaction for two common maternal exposures, and parent-of-origin effects. CL/P case-parent trios from three sites in mainland China and Taiwan were genotyped for 22 single nucleotide polymorphisms (SNPs) in IRF6. The transmission disequilibrium test was used to test for marginal effects of individual SNPs. We used PBAT to screen the SNPs and haplotypes for gene-environment (G×E) interaction and conditional logistic regression models to quantify effect sizes for SNP-environment interaction. After Bonferroni correction, 14 SNPs showed statistically significant association with CL/P. Evidence of G×E interaction was found for both maternal exposures, multivitamin supplementation and environmental tobacco smoke (ETS). Two SNPs showed evidence of interaction with multivitamin supplementation in conditional logistic regressi...Continue Reading

References

Jul 31, 1998·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·G M ShawE J Lammer
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Mar 13, 2001·Annual Review of Immunology·T TaniguchiN Tanaka
Jun 20, 2002·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Kaare Christensen, Preben Bo Mortensen
Sep 10, 2002·Nature Genetics·Shinji KondoJeffrey C Murray
May 18, 2004·BMJ : British Medical Journal·Kaare ChristensenJeffrey C Murray
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Aug 20, 2004·The New England Journal of Medicine·Theresa M ZuccheroJeffrey C Murray
Jul 12, 2005·American Journal of Medical Genetics. Part a·Michele RubiniElisa Calzolari
Aug 13, 2005·American Journal of Medical Genetics. Part a·Susan H BlantonJacqueline T Hecht
Sep 1, 2005·European Journal of Human Genetics : EJHG·Michella GhassibéMiikka Vikkula
Jan 20, 2007·Bioinformatics·Augustin Luna, Kristin K Nicodemus
Feb 7, 2007·Human Heredity·Peter KraftW James Gauderman
Apr 18, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ji Wan ParkTerri H Beaty
Jun 15, 2007·American Journal of Human Genetics·Min ShiClarice R Weinberg
Jul 27, 2007·Orthodontics & Craniofacial Research·Peter Mossey
Aug 21, 2007·American Journal of Medical Genetics. Part a·Alexandre R VieiraEduardo E Castilla
Jan 23, 2008·European Journal of Orthodontics·M PegelowA Karsten
Apr 3, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Min ShiJeffrey C Murray
Jun 28, 2008·International Journal of Epidemiology·Candice Y Johnson, Julian Little
Aug 9, 2008·American Journal of Medical Genetics. Part a·Jae Woong SullTerri H Beaty
Oct 7, 2008·Nature Genetics·Fedik RahimovJeffrey C Murray
Oct 22, 2008·Human Genetics·Marie-José H van den BoogaardRégine P M Steegers-Theunissen
Jan 1, 2009·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Wei TangWeidong Tian
May 19, 2009·American Journal of Medical Genetics. Part a·Fernanda Sarquis JeheeMaria Rita Passos-Bueno
Jun 6, 2009·Seminars in Orthodontics·Andrew C LidralSteven A Bullard
Sep 8, 2009·Journal of Dental Research·Y HuangB Shi
Nov 26, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Tonia C CarterJames L Mills

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Citations

Aug 13, 2011·American Journal of Medical Genetics. Part a·Iman SalahshourifarAhmad Sukari Halim
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
Jul 5, 2013·Pediatric Research·Matthew B WallensteinSuzan L Carmichael
Apr 14, 2012·Annals of Human Genetics·Oivind SkareHåkon Kristian Gjessing
Dec 27, 2011·The Indian Journal of Medical Research·David M Iovannisci
Sep 4, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Youssef A Kousa, Brian C Schutte
Sep 3, 2011·Trends in Molecular Medicine·Elisabeth MangoldMarkus M Nöthen
Aug 19, 2015·Brazilian Journal of Otorhinolaryngology·Daniella Reis Barbosa MartelliHercílio Martelli Júnior
Nov 22, 2012·American Journal of Medical Genetics. Part a·José A Velázquez-AragónAriadna González-del Angel
Jan 28, 2014·European Journal of Oral Sciences·Bernardette Estandia-OrtegaAriadna González-Del Angel
Jan 11, 2011·Trends in Genetics : TIG·Carole Ober, Donata Vercelli
Jun 13, 2015·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Nicola Marie StockJonathan Sandy
Jun 20, 2015·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Sanmati R CuddapahNathaniel H Robin
Feb 25, 2014·International Journal of Environmental Health Research·Anna Materna-KirylukAnna Latos-Bieleńska
May 8, 2016·Journal of Dental Research·J A Velázquez-AragónA González-Del Angel
Oct 3, 2018·Genetic Epidemiology·Jenna C CarlsonElizabeth J Leslie
Oct 1, 2011·The Journal of Craniofacial Surgery·Liborio StuppiaStefano Tetè
Apr 3, 2020·BMJ Open·Satomi YoshidaUNKNOWN Japan Environment and Children's Study Group
Oct 22, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ádám Berniczei-RoykóUte Ulrike Botzenhart
Feb 17, 2019·International Journal of Environmental Research and Public Health·Ren ZhouTerri H Beaty
Oct 28, 2019·Birth Defects Research·Philip J LupoMary M Jenkins
Aug 28, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Teresa KruseBert Braumann
Apr 24, 2018·American Journal of Medical Genetics. Part a·Amy M PadulaGary M Shaw
Dec 12, 2020·Frontiers in Cell and Developmental Biology·S T RatermanJohannes W Von den Hoff
Mar 9, 2021·International Journal of Pediatric Otorhinolaryngology·Ginila T RajuSolomon F D Paul
Sep 10, 2019·Brazilian Journal of Otorhinolaryngology·João Felipe BezerraAdriana Augusto de Rezende

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