Evidence of hair loss after subacute exposure to 2-chloroethyl ethyl sulfide, a mustard analog, and beneficial effects of N-acetyl cysteine

Journal of Biochemical and Molecular Toxicology
Diptendu ChatterjeeSalil K Das

Abstract

Mustard gas has been used as a vesicant chemical warfare agent. However, a suitable biomarker for monitoring mustard gas exposure is not known. We observed that the hairs of the guinea pigs exposed intratracheally to subacute doses of 2-chloroethyl ethyl sulfide (CEES), a mustard analog, came out very easily though there was no sign of skin lesions or skin damage. Also the hairs looked rough and dry and lost the shiny glaze. There was no recovery from this hair loss, though the animals never became hairless, following CEES exposure. Hairs were observed in this study both visually and with light microscopy. Treatment with N-acetylcysteine (NAC) prior to CEES exposure could prevent the hair loss completely. Hence, sudden hair loss might be a good biomarker for subacute exposure of mustard gas to subjects at risks when the victims might have no other visible symptom of toxicity.

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Jun 20, 2003·Journal of Biochemical and Molecular Toxicology·Salil K DasDiptendu Chatterjee

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Citations

May 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Roumen BalanskySilvio De Flora
Dec 17, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Neera Tewari-SinghRajesh Agarwal
Oct 27, 2010·The Journal of Pharmacology and Experimental Therapeutics·Neera Tewari-SinghRajesh Agarwal
Apr 18, 2013·Cutaneous and Ocular Toxicology·Hassan GhasemiTooba Ghazanfari
Jan 24, 2008·Journal of Evaluation in Clinical Practice·Stephen J Genuis
Nov 25, 2017·Drug and Chemical Toxicology·Shlomit DachirTamar Kadar

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