Evidence of hepatitis A virus circulation in central Argentina: seroprevalence and environmental surveillance

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Laura A YanezViviana E Ré

Abstract

Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. In order to get insight into the local circulation of this virus after four years of the official introduction of the vaccine, the aims of this study were to provide information on HAV immune status of the adult population of Córdoba city and to conduct environmental surveillance of HAV in sewage and river samples in the same region. The prevalence of anti-HAV was determined by EIA in 416 samples of people (without prior vaccination) from Córdoba city (2009-2010). Spline regression models were estimated under generalized additive models. Environmental surveillance was conducted in river and sewage samples collected in the same period. Viral detection was performed by RT-Nested PCR of the 5'UTR. In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p<0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05-1.25). This prevalence decreased in younger age groups, especially in the high-income population. Environmental monitoring revealed the presence of HAV (IA) in 20.8% and 16.1% of wastewater and river samples, ...Continue Reading

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Citations

Sep 13, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maribel G Martínez WassafViviana E Ré
Oct 20, 2017·Environmental Monitoring and Assessment·Christine Susan FagnantJohn Scott Meschke
Mar 4, 2018·Cold Spring Harbor Perspectives in Medicine·Kathryn H Jacobsen
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Paula Andrea BáezMaría Cristina Navas
Dec 23, 2017·Applied and Environmental Microbiology·G MasachessiV Ré
Jan 7, 2019·Food and Environmental Virology·Jill C FalmanJohn Scott Meschke
Sep 22, 2020·Expert Review of Vaccines·Anar AndaniKathryn H Jacobsen
Dec 17, 2020·Human Vaccines & Immunotherapeutics·Christian HerzogPierre Van Damme
Jul 19, 2021·The Science of the Total Environment·Maximiliano Giraud-BilloudIsrael A Vega
Aug 28, 2021·Food and Environmental Virology·Robertina Viviana CammarataViviana Andrea Mbayed

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