Evidence of impaired hypoxic vasodilation after intermediate-duration hypoxic exposure in humans

American Journal of Physiology. Heart and Circulatory Physiology
Geoffrey S GilmartinJ Woodrow Weiss

Abstract

Systemic hemodynamics, including forearm blood flow and ventilatory parameters, were evaluated in 21 subjects before and after exposure to 8 h of poikilocapnic hypoxia. To evaluate the role of sympathetic nervous system activation in the changes, in 10 of these subjects, we measured muscle sympathetic nerve activity (MSNA) before and after exposure, and the remaining 11 subjects received intra-arterial phentolamine infusion in the brachial artery to define vascular tone in the absence of sympathetically mediated vasoconstriction. Short-term ventilatory acclimatization occurred as evidenced by a decrease in resting Pco(2) (from 42 +/- 1.4 to 37 +/- 0.96 mmHg) and by an increase in the slope of the ventilatory response to acute hypoxia [from 0.7 +/- 0.1 to 1.2 +/- 0.2 l.min(-1).%Sp(O(2)) (blood O(2) saturation from pulse oximetry)] after exposure. Subjects demonstrated a significant increase in resting heart rate (from 61 +/- 2 to 65 +/- 2 beats/min) and diastolic blood pressure (from 64.8 +/- 2.7 to 70.4 +/- 2.0 mmHg). MSNA did not change significantly after exposure, although there was a trend toward a decrease in burst frequency (from 19.8 +/- 4.1 to 14.3 +/- 1.2 bursts/min). Forearm vascular resistance showed a significant de...Continue Reading

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Citations

Jun 10, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Geoffrey S GilmartinJ Woodrow Weiss
Sep 2, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Brian E HuntJ Woodrow Weiss
Jan 21, 2010·Physiological Reviews·Jerome A DempseyChristopher P O'Donnell
Sep 30, 2018·The Journal of Physiology·Shaelynn M ZouboulesTrevor A Day
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Renaud TamisierJ Woodrow Weiss
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Can Ozan TanJ Andrew Taylor
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan

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