Evidence of impaired sense of smell in hereditary angioedema

Allergy
C PerriconeYehuda Shoenfeld

Abstract

Hereditary angioedema (HAE) is an autosomal-dominant disorder resulting from C1-inhibitor (C1INH) deficiency. Smell impairments were found in patients affected with systemic lupus erythematosus, that, similarly to HAE, is characterized by the activation of the classical complement pathway with C4 consumption. In this study, we aimed at evaluating the sense of smell in patients with HAE. Thirty patients with HAE and 30 healthy age- and sex-matched controls were evaluated for olfactory functions using the 3-stages Sniffin'-Sticks kit (threshold, discrimination, and identification [TDI]). TDI scores were analyzed according to complement levels (C1INH, C3, C4 and CH50), Beck depression inventory (BDI-II) and danazol treatment. A significant decrease in olfactory function was observed in patients affected with HAE compared with controls in total TDI score (P < 0.001), and in the discrimination (P < 0.001) and identification scores (P = 0.012). Anosmia was present only in patients with HAE (3.3%) who also exhibited more frequently hyposmia (53.3%vs 3.3%, P < 0.0001). Complement levels were reduced in patients with HAE. C4 serum levels showed positive correlation with total TDI score (P < 0.001), and with discrimination (P = 0.002) an...Continue Reading

References

Apr 1, 1991·The Journal of Allergy and Clinical Immunology·M CicardiA Agostoni
Apr 1, 1989·Immunology Today·Y Shoenfeld, D A Isenberg
Apr 22, 1995·Lancet·J LehrnerI Podreka
May 26, 1999·Clinical and Experimental Immunology·L BergamaschiniA Agostoni
Apr 18, 2000·Lancet·P E Polani
Oct 7, 2000·The American Journal of Medicine·T R PachecoL A Lee
May 5, 2001·Genome Research·G GlusmanD Lancet
Jun 26, 2001·Genome Biology·S ZozulyaT Nguyen
Oct 31, 2003·Nature Immunology·Peter C Doherty
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Angelo AgostoniLorenza Zingale
Jul 4, 2006·Clinical Genetics·S GuarinoG Novelli
Nov 2, 2006·American Journal of Reproductive Immunology : AJRI·Yehuda ShoenfeldPer Luigi Meroni
Nov 18, 2006·Autoimmunity Reviews·Rael D Strous, Yehuda Shoenfeld
Jul 31, 2007·The Journal of Allergy and Clinical Immunology·Maria Domenica GuarinoRoberto Perricone
Dec 2, 2008·Clinical and Experimental Immunology·G IngramB P Morgan
Dec 23, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Samuel-Datum MoscavitchYehuda Shoenfeld
Jan 8, 2009·Autoimmunity·Oscar-Danilo Ortega-HernandezYehuda Shoenfeld
Mar 11, 2009·Physiology & Behavior·Richard L Doty, E Leslie Cameron
May 1, 2009·Arthritis and Rheumatism·Netta ShoenfeldYehuda Shoenfeld
Sep 16, 2009·Rheumatology·Usama F KamelRhiannon Whitaker

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Citations

Dec 29, 2011·Clinical Reviews in Allergy & Immunology·Yehuda Shoenfeld
Jul 12, 2013·Clinical Reviews in Allergy & Immunology·Carlo SelmiPier Luigi Meroni
Mar 10, 2012·Immunotherapy·Carlo Perricone, Roberto Perricone
Dec 13, 2012·Clinical Reviews in Allergy & Immunology·Carlo PerriconeYehuda Shoenfeld
Nov 27, 2014·Immunologic Research·Howard AmitalYehuda Shoenfeld
Apr 2, 2015·Autoimmunity Reviews·Paola TriggianeseRoberto Perricone
Nov 30, 2005·BMC Nuclear Medicine·Mohammad EftekhariDavood Beiki
Apr 27, 2016·Clinical Reviews in Allergy & Immunology·Anastasios E Germenis, Matthaios Speletas
Mar 6, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Esin YalcinkayaThomas Hummel
Jan 19, 2020·Orphanet Journal of Rare Diseases·Paola TriggianeseRoberto Perricone
May 3, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joseph A Roche, Renuka Roche

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