Evidence of improving quality of reporting of randomized controlled trials in subfertility

Human Reproduction
Sofia DiasAndy Vail

Abstract

The quality of randomized controlled trials (RCTs) in subfertility and their suitability for inclusion in meta-analyses have been assessed in the past and found to be insufficient. Our aim was to assess whether this quality has improved over time, particularly since the publication of the Consolidated Standards of Reporting Trials (CONSORT) statement, and to assess what proportion of trials could be included in the meta-analyses of pregnancy outcomes such as those included in Cochrane Reviews. A selection of subfertility trials published in 1990, 1996 and 2002 was collected from the Cochrane Menstrual Disorder and Subfertility Group (MDSG) database. Only trials published in English as full journal articles, claiming to be randomized and reporting on pregnancy outcomes, were included. One hundred and sixty-four trials met our inclusion criteria. Twenty-four (15%) were found not to be randomized, despite claims, and only 10 trials (6%) provided adequate details on the methods of randomization and allocation concealment. Of these, only three had sufficient details extractable to allow for an intention-to-treat analysis of the outcome 'live birth'. Although an improvement in some subfertility-specific issues was observed, the quali...Continue Reading

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Citations

Aug 16, 2008·BMC Psychiatry·Rebecca J Syed SheriffUNKNOWN PRACTIHC Mental Health Group
Nov 26, 2009·Trials·Anna Partsinevelou, Elias Zintzaras
Feb 5, 2016·Human Reproduction Update·Athanasios PapathanasiouSiladitya Bhattacharya
Dec 15, 2010·Journal of Clinical Epidemiology·Anne M MoseleyMark R Elkins
Jan 9, 2010·Fertility and Sterility·Jane F ClarkePeter Herbison
Aug 12, 2008·Statistics in Medicine·Sofia DiasAndy Vail
Dec 3, 2014·Fertility and Sterility·Demian GlujovskyAgustín Ciapponi
Jun 19, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Gaoquan LuoJingchun Zeng
Nov 18, 2008·Journal of Clinical Epidemiology·Matthew E FalagasEleni Ioannidou
Jul 29, 2017·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Dec 17, 2014·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Marian G ShowellCindy Farquhar
Mar 14, 2019·The Cochrane Database of Systematic Reviews·Roos M SmitsMarian G Showell
Jun 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Lorena P RiosLehana Thabane
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Neil JohnsonBen Willem J Mol
Aug 28, 2020·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Feb 27, 2016·The Cochrane Database of Systematic Reviews·Maartje CissenMadelon van Wely
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Guowei LiLehana Thabane

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