Evidence of increased substrate availability to in vitro-derived bovine foetuses and association with accelerated conceptus growth

Reproduction : the Official Journal of the Society for the Study of Fertility
Marcelo BertoliniGary B Anderson

Abstract

Changes in placental development have been associated with foetal abnormalities after in vitro embryo manipulations. This study was designed to investigate bovine conceptus development and substrate levels in plasma and fluids in in vivo- and in vitro-produced (IVP) concepti and neonates. In vivo-produced and IVP embryos were derived by established embryo production procedures. Pregnant animals from both groups were slaughtered on days 90 or 180 of gestation, or allowed to go to term. Conceptus and neonatal physical traits were recorded; foetal, maternal and neonatal blood, and foetal fluids were collected for the determination of blood and fluid chemistry, and glucose, fructose and lactate concentrations. Placental transcripts for specific glucose transporters were determined by quantitative RT-PCR. No significant differences in uterine and conceptus traits were observed between groups on day 90. On day 180, larger uterine, placental and foetal weights, and an increase in placental gross surface area (SA) in IVP pregnancies were associated with increased glucose and fructose accumulation in foetal plasma and associated fluids, with no differences in the expression of components of the glucose transporter system. Therefore, the...Continue Reading

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Citations

Mar 29, 2007·Reproduction, Fertility, and Development·Jeremy G B ThompsonKaren L Kind
Mar 29, 2007·Reproduction, Fertility, and Development·Michael E SymondsHelen Budge
Sep 8, 2012·Reproduction, Fertility, and Development·Míryan L V AlbertoMaria A Miglino
Mar 28, 2007·Cloning and Stem Cells·Cynthia A BatchelderGary B Anderson
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Nov 12, 2013·Journal of Dairy Science·L BonillaP J Hansen
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Marcelo BertoliniGary B Anderson
Nov 11, 2014·Annual Review of Animal Biosciences·Jonathan R Hill
Jul 19, 2014·Human Reproduction Update·Elpiniki Chronopoulou, Joyce C Harper
Jul 3, 2013·The Veterinary Clinics of North America. Food Animal Practice·Jenne D De Koster, Geert Opsomer
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Jul 26, 2011·Molecular Reproduction and Development·Le JiangX Cindy Tian
Nov 4, 2005·Theriogenology·Peter W FarinCharlotte E Farin
Feb 20, 2018·Molecular Reproduction and Development·Veronique Duranthon, Pascale Chavatte-Palmer
Apr 11, 2019·Journal of Animal Science·Alan D EalySarah R McCoski
Apr 27, 2017·Reproduction, Fertility, and Development·R P C GergerM Bertolini

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