PMID: 15378118Sep 21, 2004Paper

Evidence of left ventricular dysfunction in asymptomatic elderly patients with non-insulin-dependent diabetes mellitus

Angiology
Haralampos I KarvounisGeorgios E Louridas

Abstract

Diabetic cardiomyopathy is a distinct entity in diabetic patients with congestive heart failure, who have no angiographic evidence of significant coronary artery stenosis. The aim of this study was to evaluate left ventricular (LV) function in 24 elderly patients (mean age 67 +/- 2 years) with type 2 diabetes, who were asymptomatic and had no history of hypertension, or coronary or valvular heart disease. LV systolic indices (ejection fraction [EF] and fractional shortening [FS]), diastolic indices (E wave, A wave, E/A ratio, isovolumic relaxation time [IVRT] and deceleration time [DT]) and the myocardial performance index (MPI) were evaluated with echocardiography. Compared to controls (24 age- and gender-matched normal subjects), the E wave was reduced (0.60 +/- 0.10 m/sec vs 0.72 +/- 0.08 m/sec, p < 0.05), the A wave was increased (0.77 +/- 0.07 m/sec vs 0.68 +/- 0.06 m/sec, p < 0.05), the E/A ratio was decreased (0.78 +/- 0.20 vs 1.06 +/- 0.18, p < 0.001) and both IVRT and DT were prolonged (0.115 +/- 0.01 sec vs 0.09 +/- 0.01 sec, p < 0.001 and 0.240 +/- 0.04 sec vs 0.180 +/- 0.03 sec, p < 0.001, respectively). The MPI was significantly increased (0.640 +/- 0.170 vs 0.368 +/- 0.098, p < 0.001). LV diastolic function and th...Continue Reading

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Citations

May 5, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hisashi MasugataMasakazu Kohno
Jun 21, 2005·International Journal of Clinical Practice·G I VarugheseG Y H Lip
Sep 4, 2007·European Journal of Heart Failure·I S ThrainsdottirL Rydén
Jun 17, 2006·International Journal of Cardiology·Theodoros D KaramitsosGeorgios E Louridas
Dec 7, 2005·Circulation·André Pascal KengneJean-Claude Mbanya
Nov 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Yin KangBradley B Keller
Feb 23, 2005·Expert Review of Cardiovascular Therapy·Sarah J Goodlin
Mar 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Pan-Pan HaoYun Zhang
Jul 19, 2021·Basic Research in Cardiology·Ioanna AndreadouRainer Schulz

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