PMID: 9541106Apr 16, 1998Paper

Evidence of linkage of the inflammatory bowel disease susceptibility locus on chromosome 16 (IBD1) to ulcerative colitis

Journal of Medical Genetics
M M MirzaC G Mathew

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) of unknown aetiology which are characterised by chronic inflammation of the gastrointestinal tract. Epidemiological studies suggest the presence of a genetic component in the aetiology of both CD and UC. A susceptibility gene for Crohn's disease has recently been mapped to the pericentromeric region of chromosome 16 (IBD1), and this finding has been replicated in two subsequent studies. Although CD and UC are distinct clinical entities, the fact that both disorders occur in a significant proportion of families with multiple cases of IBD suggests that overlapping sets of susceptibility genes may be involved. We have addressed this question for IBD1 by typing eight microsatellite markers from the locus in 70 kindreds affected with either UC only or with both UC and CD and analysing the data for linkage by both non-parametric and parametric methods. Evidence for linkage was detected in families affected with only UC, with a mean proportion of 0.70 affected sib pairs sharing alleles identical by descent at D16S3136 (p=0.01), and a peak non-parametric linkage score of 2.02 at D16S3120 with the GENEHUNTER program (p=0.02). The estimated sib relativ...Continue Reading

References

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Citations

Jan 15, 1999·Pathology Oncology Research : POR·R Naidoo, R Chetty
Sep 1, 2000·European Journal of Internal Medicine·A PeraG Rocca
Oct 7, 2006·Current Opinion in Gastroenterology·S Schreiber, J Hampe
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May 7, 2013·Journal of Crohn's & Colitis·Rebecca AbellJeffrey Morganstern
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Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Miodraga Stefanovska PetkovskaVesna Velikj Stefanovska
May 26, 2004·Best Practice & Research. Clinical Gastroenterology·Gary E Wild, John D Rioux
Feb 14, 2002·Rheumatic Diseases Clinics of North America·Patrick M GaffneyTimothy W Behrens
Jun 11, 2014·Best Practice & Research. Clinical Gastroenterology·Jimmy Z Liu, Carl A Anderson
Jun 4, 2016·Expert Review of Gastroenterology & Hepatology·Tommaso GabbaniVito Annese
Aug 15, 2003·World Journal of Gastroenterology : WJG·Chang-Qing ZhengGin-Ge Gu
Sep 23, 2003·Clinical Chemistry·Orazio PalmieriPaolo Fortina
May 31, 2001·Alimentary Pharmacology & Therapeutics·T AhmadD P Jewell
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Mar 21, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·H YangJ I Rotter

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