Evidence of Ljungan virus specific antibodies in humans and rodents, Finland

Journal of Medical Virology
Anne J JääskeläinenOlli Vapalahti


Ljungan virus (LV, genus Parechovirus, family Picornaviridae) is considered currently to be a rodent-borne virus. Despite suggested human disease associations, its zoonotic potential remains unclear. To date, LV antibody prevalence in both humans and rodents has not been studied. In this study, two different LV immunofluorescence assays (LV IFAs) were developed with LV genotypes 1 (LV strain 87-012G) and 2 (LV strain 145SLG), and cross-neutralization and -reaction studies were carried out with LV strain 145SLG. Finally, a panel of 37 Finnish sera was screened for anti-LV antibodies using two different LV IFAs (LV 145SLG and LV 87-012G) and a neutralization (NT) assay (LV 145SLG), and 50 samples from Myodes glareolus by LV IFA (LV 145SLG). The LV seroprevalence study showed 38% and 18% positivity in humans and M. glareolus, respectively. LV IFAs and NT assays were compared, and the results were in good agreement. The data are the first evidence of humans and rodents coming into contact with LV in Finland. Additional studies are required in order to acquire a better understanding of the prevalence, epidemiological patterns and possible disease association of LV infections.


Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T HyypiäG Stanway
Jun 11, 1999·Journal of Virology·G Stanway, T Hyypiä
Mar 26, 2003·The Journal of General Virology·E Susanne JohanssonA Michael Lindberg
May 15, 2003·International Journal of Experimental Diabesity Research·Bo NiklassonAke Lernmark
Apr 20, 2004·Biochemical and Biophysical Research Communications·E Susanne JohanssonA Michael Lindberg
May 26, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Austin L Hughes
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K S M BenschopK C Wolthers
Feb 22, 2007·Journal of Medical Virology·Sisko TauriainenHeikki Hyöty
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Apr 5, 2007·Diabetologia·Bo NiklassonW Klitz
Apr 12, 2008·Journal of Virological Methods·Conny TolfA Michael Lindberg
Jan 13, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Annika SamsioeBo Niklasson
Feb 6, 2009·Emerging Infectious Diseases·Jan Felix DrexlerChristian Drosten
Jun 23, 2009·Virology Journal·Alexander L GreningerJoseph L DeRisi
Sep 20, 2011·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·P HeymanA Vaheri
Mar 13, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Pekka KolehmainenSisko Tauriainen
Jul 5, 2012·Reviews in Medical Virology·Antti VaheriOlli Vapalahti

❮ Previous
Next ❯


Apr 3, 2014·Vector Borne and Zoonotic Diseases·Kristian M ForbesOtso Huitu
Jan 30, 2015·Vector Borne and Zoonotic Diseases·Nguyen Van CuongJuliet E Bryant
Sep 17, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kieran C PounderLorraine M McElhinney
Mar 20, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Lili ZhengHong Xin
Oct 11, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cristina FevolaAntti Vaheri
Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Jun 4, 2020·Vector Borne and Zoonotic Diseases·Cristina FevolaHeidi C Hauffe
Oct 11, 2020·Animals : an Open Access Journal From MDPI·Maciej GrzybekAnna Bajer
May 23, 2021·The Journal of General Virology·Annika LundstigAnna-Lena Nilsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.