Evidence of Ljungan virus specific antibodies in humans and rodents, Finland

Journal of Medical Virology
Anne J JääskeläinenOlli Vapalahti

Abstract

Ljungan virus (LV, genus Parechovirus, family Picornaviridae) is considered currently to be a rodent-borne virus. Despite suggested human disease associations, its zoonotic potential remains unclear. To date, LV antibody prevalence in both humans and rodents has not been studied. In this study, two different LV immunofluorescence assays (LV IFAs) were developed with LV genotypes 1 (LV strain 87-012G) and 2 (LV strain 145SLG), and cross-neutralization and -reaction studies were carried out with LV strain 145SLG. Finally, a panel of 37 Finnish sera was screened for anti-LV antibodies using two different LV IFAs (LV 145SLG and LV 87-012G) and a neutralization (NT) assay (LV 145SLG), and 50 samples from Myodes glareolus by LV IFA (LV 145SLG). The LV seroprevalence study showed 38% and 18% positivity in humans and M. glareolus, respectively. LV IFAs and NT assays were compared, and the results were in good agreement. The data are the first evidence of humans and rodents coming into contact with LV in Finland. Additional studies are required in order to acquire a better understanding of the prevalence, epidemiological patterns and possible disease association of LV infections.

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Citations

Apr 3, 2014·Vector Borne and Zoonotic Diseases·Kristian M ForbesOtso Huitu
Jan 30, 2015·Vector Borne and Zoonotic Diseases·Nguyen Van CuongJuliet E Bryant
Sep 17, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kieran C PounderLorraine M McElhinney
Mar 20, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Lili ZhengHong Xin
Oct 11, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cristina FevolaAntti Vaheri
Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Jun 4, 2020·Vector Borne and Zoonotic Diseases·Cristina FevolaHeidi C Hauffe
Oct 11, 2020·Animals : an Open Access Journal From MDPI·Maciej GrzybekAnna Bajer
May 23, 2021·The Journal of General Virology·Annika LundstigAnna-Lena Nilsson

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