Evidence of multiple introductions and autochthonous transmission of the HIV type 1 CRF02_AG clade in Brazil

AIDS Research and Human Retroviruses
Edson DelatorreJosé Carlos Couto-Fernandez

Abstract

HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the early detection of newly emerging viral lineages.

References

Aug 26, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M G MorgadoV Bongertz
Dec 19, 2002·AIDS Research and Human Retroviruses·Monick Lindenmeyer GuimarãesUNKNOWN Brazilian Network for HIV Isolation and Characterization
Apr 18, 2003·AIDS·Rodrigo M BrindeiroUNKNOWN Brazilian Network for Drug Resistance Surveillance
Oct 8, 2003·Systematic Biology·Stéphane Guindon, Olivier Gascuel
Jun 28, 2005·Nucleic Acids Research·Stéphane GuindonOlivier Gascuel
Feb 16, 2006·AIDS Research and Human Retroviruses·José Carlos Couto-FernandezMariza G Morgado
Mar 17, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Claudia C BarretoEster C Sabino
Jun 21, 2006·Systematic Biology·Maria Anisimova, Olivier Gascuel
Apr 10, 2008·Molecular Biology and Evolution·David Posada
Oct 19, 2010·AIDS Research and Human Retroviruses·L F M BrígidoUNKNOWN São Paulo HIV Salvage Workgroup
Feb 8, 2011·AIDS·Joris HemelaarUNKNOWN WHO-UNAIDS Network for HIV Isolation and Characterisation

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Citations

Aug 31, 2013·AIDS Research and Human Retroviruses·Victor F PimentelMonick L Guimarães
Sep 10, 2015·AIDS Research and Human Retroviruses·Edson DelatorreMariza G Morgado
Nov 25, 2014·AIDS Research and Human Retroviruses·María F FernándezPaula C Aulicino
May 18, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Daiana MirGonzalo Bello
Jun 5, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Edson DelatorreMariza G Morgado
Mar 23, 2017·AIDS Research and Human Retroviruses·Edson DelatorreGonzalo Bello
Apr 20, 2019·Frontiers in Microbiology·Elena DelgadoUNKNOWN Spanish Group for the Study of New HIV Diagnoses

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Datasets Mentioned

BETA
HM534195

Methods Mentioned

BETA
genotyping

Software Mentioned

jModeltest
PhyML

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