PMID: 9650059Jul 3, 1998Paper

Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols

International Journal for Parasitology
J GillE Lacey

Abstract

Three isolates of Haemonchus contortus selected for avermectin resistance in sheep were compared in three in vitro pharmacological tests previously shown to discriminate between field isolates of H. contortus resistant and susceptible to the avermectins. Two isolates, F7-A and IVC, were selected for avermectin resistance in the laboratory from a reference susceptible isolate using suboptimal doses of ivermectin (LD95) for 7 and 16 generations, respectively. In these isolates avermectin resistance was not associated with a decreased sensitivity to avermectin inhibition of larval development or L3 motility but was associated with an increased sensitivity to paraherquamide. The third isolate, Warren, was derived from an overwhelmingly avermectin-susceptible, mixed species field isolate in a single generation by propagating the small number of survivors of a 0.2 mg/kg ivermectin treatment (i.e. 10 x LD95). This isolate, like previously characterised avermectin-resistant H. contortus isolates derived from the field in South Africa and Australia, showed a markedly reduced sensitivity to avermectin inhibition of larval development and L3 motility, as well as an increased sensitivity to paraherquamide. These results suggest that averme...Continue Reading

References

Aug 26, 1983·Science·W C CampbellT A Jacob
Sep 1, 1995·Veterinary Parasitology·W L ShoopM H Fisher
Sep 1, 1993·Australian Veterinary Journal·L F Le Jambre
Jun 26, 1993·The Veterinary Record·G A ConderS S Johnson
May 1, 1993·Parasitology Today·W L Shoop

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Citations

Feb 27, 1999·International Journal for Parasitology·N C Sangster
Feb 17, 2000·International Journal for Parasitology·L F Le JambreP Baker
Sep 27, 2003·Molecular and Biochemical Parasitology·William J BlackhallRobin N Beech
May 14, 1999·Parasitology Today·N C Sangster, J Gill
Aug 23, 2001·Veterinary Parasitology·R Prichard, A Tait
Dec 26, 2001·Veterinary Parasitology·S RanjanK L Simkins
Nov 15, 2001·Veterinary Parasitology·T G Geary, D P Thompson
Aug 24, 1999·Veterinary Parasitology·T G GearyD P Thompson
Apr 6, 2006·Journal of Veterinary Internal Medicine·Sherrill A FlemingMike Rings
Feb 7, 2001·Clinical Microbiology Reviews·S Geerts, B Gryseels
Oct 24, 2007·Veterinary Parasitology·A M Van ZeverenJ Vercruysse
Oct 31, 2006·The Veterinary Clinics of North America. Food Animal Practice·Thomas M Craig
Aug 8, 2006·International Journal for Parasitology·John Stuart Gilleard
Mar 23, 2013·Experimental Parasitology·I Jana I JanssenGeorg von Samson-Himmelstjerna
Sep 19, 2006·Life Sciences·Abdul JabbarMusarrat Afaq
Nov 27, 2004·Research in Veterinary Science·G C Coles
Dec 22, 2017·Journal of Veterinary Pharmacology and Therapeutics·J P MochelI Schmerold
Jun 10, 2003·The Journal of Comparative Neurology·Virginia PortilloAdrian J Wolstenholme
Oct 13, 2006·Current Opinion in Infectious Diseases·E Michael
Feb 5, 2021·Animals : an Open Access Journal From MDPI·Konstantinos V ArsenopoulosElias Papadopoulos
Jul 10, 1999·Clinical Microbiology Reviews·L R Hall, E Pearlman

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