Evidence of Nef truncation in human immunodeficiency virus type 2 infection

The Journal of Infectious Diseases
W M SwitzerW Heneine

Abstract

Human immunodeficiency virus (HIV)-2 differs from HIV-1 in its relative lower transmissibility and pathogenicity. To understand the virologic basis of these differences, the nef gene from HIV-2-seropositive persons was analyzed because of its importance for disease progression in the genetically related simian immunodeficiency virus (SIV[MAC]). Proviral nef sequences from 60 HIV-2-infected persons were amplified from peripheral blood lymphocytes, and nef open-reading frames were screened by a transcription and translation assay for the presence of full-length (32- to 36-kDa) or truncated (<32 kDa) Nef proteins. Overall, 6 (10%) of 60 persons had truncated Nef proteins; of these, 5 were among the 36 asymptomatic subjects (13.9%) and only 1 was among the 24 symptomatic subjects (4.2%) (P =.23). The results of this study document the presence of defective nef genes in HIV-2 infections with a prevalence higher than that previously seen in HIV-1-infected cohorts of long-term nonprogressors or patients with AIDS.

Citations

Sep 2, 1998·Current Opinion in Immunology·H C WhittleS Rowland-Jones
Sep 30, 2008·AIDS Research and Human Retroviruses·C V SanthoshRobin Mukhopadhyaya
Apr 11, 2009·Retrovirology·Jan SchmökelFrank Kirchhoff
May 25, 2002·The Journal of General Virology·Jacqueline D Reeves, Robert W Doms
Sep 2, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·V ShanmugamW Heneine
Apr 15, 2003·The Journal of General Virology·Elizabeth PaduaNeil Berry
Aug 6, 1998·Journal of Biomedical Science·N B LarsenJ J Docherty

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