PMID: 8946581Oct 1, 1996Paper

Evidence of nitric oxide in the exhaled gas of Asian elephants (Elephas maximus)

Respiration Physiology
K LewandowskiK J Falke

Abstract

Nitric oxide (NO) produced in the respiratory tract is released into the respiratory gases of humans, rabbits, guinea-pigs, and rats. We analysed the NO concentrations in the exhaled gas of four awake Asian elephants. Two methods were employed: (1) exhaled gas was sampled from the elephants' trunks with a 1 L syringe and analysed for NO concentrations by chemiluminescence; (2) respiratory gas was continuously aspirated via a thin plastic tube positioned within the trunk and on-line analysed for NO concentrations by chemiluminescence. Syringe sampling (n = 4), when corrected for dilution by ambient air using linear regression analysis, revealed a mean NO concentration of 31 parts per billion (ppb); highest exhalatory concentrations measured during continuous suctioning were 27 and 28 ppb (n = 2). The exhaled NO concentrations in elephants are similar to those found in humans measured with a comparable technique. This supports the hypothesis that a size-independent 'normal value' of endogenous NO is provided in the airways which may contribute to regulation of pulmonary ventilation and perfusion by autoinhalation in some mammals.

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Citations

Nov 21, 1997·Acta Anaesthesiologica Scandinavica·U SchedinL E Gustafsson
Dec 24, 1997·Acta Paediatrica·U SchedinC Frostell
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·W SteudelW M Zapol
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·Maria DejaKlaus Lewandowski
Jul 31, 2003·American Journal of Respiratory and Critical Care Medicine·Jean-Jacques Rouby
Jun 7, 2008·Respiratory Physiology & Neurobiology·K J FalkeW M Zapol
Dec 10, 1999·Pulmonary Pharmacology & Therapeutics·M Bernareggi, G Cremona
Sep 20, 2012·Journal of Breath Research·Nhât-Nam Le-DongAnh Tuan Dinh-Xuan
Apr 13, 2021·Advanced Biology·Aylen Lisset Jaimes-MogollónRadu Ionescu

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