PMID: 9525245Apr 3, 1998Paper

Evidence of potential regulation by interleukin-4 of the soluble intercellular adhesion molecule 1 level in patients with seasonal allergic rhinitis under provocation by a small amount of natural allergen

The Annals of Otology, Rhinology, and Laryngology
M KatoI Nakashima

Abstract

Interleukin-4 (IL-4) and intercellular adhesion molecule 1 (ICAM-1) are assumed to be involved in the pathogenesis of allergic disease. In this study, we examined the potential link between IL-4 and soluble ICAM-1 (sICAM-1) levels in patients with allergic rhinitis. The levels of sICAM-1 and IL-4 in sera and in nasal epithelial lining fluids (ELF) from 12 patients with Japanese cedar pollinosis were measured preseason through postseason, and the results were compared with those from 7 healthy subjects. In sera from the allergic subjects, the levels of sICAM- 1 were upregulated during the early part of the season and downregulated during the middle of the season, with upregulation of the IL-4 levels. Moreover, a negative correlation was found between the serum sICAM-1 levels and serum IL-4 levels during the middle (r = -.80) and late (r = -.73) parts of the season. In ELF from allergic subjects, the levels of sICAM-1 were significantly upregulated during the early and middle parts of the season, and began to be downregulated during the late part of the season, with upregulation of the levels of IL-4. In conclusion, IL-4 possibly acts as a potential suppressor of sICAM-1 in the pathogenesis of seasonal allergic rhinitis, at least...Continue Reading

References

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Aug 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KatoI Nakashima
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Sep 1, 1995·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·M KatoI Nakashima
Dec 1, 1996·Archives of Otolaryngology--head & Neck Surgery·M KatoI Nakashima

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Citations

Apr 9, 2001·Allergy·P H HowarthD Dokic
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BensonL O Cardell
Feb 5, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Nur Sabrina IdroseShyamali C Dharmage
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization

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