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Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism

The New England Journal of Medicine

Apr 17, 1986

Joseph L NadlerRichard C Horton

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Abstract

Hyporeninemic hypoaldosteronism is an important cause of hyperkalemia and is characterized by low renin secretion. We found that prostacyclin, a potent vasodilator and renin secretagogue, was markedly reduced--as reflected by its stable urinary metabolite 6-keto-prostaglandin F1 alpha--...read more

Mentioned in this Paper

Cell Secretion
Blood Pressure
Deficiency Diseases
Renin Measurement
Prostaglandin E2 Measurement
Norepinephrine
Hyperkalemia
Renal Circulation
Creatinine
Norepinephrine, (+, -)-Isomer
Paper Details
References
  • References35
  • Citations21
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  • References35
  • Citations21
123

Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism

The New England Journal of Medicine

Apr 17, 1986

Joseph L NadlerRichard C Horton

PMID: 3515183

DOI: 10.1056/nejm198604173141604

Abstract

Hyporeninemic hypoaldosteronism is an important cause of hyperkalemia and is characterized by low renin secretion. We found that prostacyclin, a potent vasodilator and renin secretagogue, was markedly reduced--as reflected by its stable urinary metabolite 6-keto-prostaglandin F1 alpha--...read more

Mentioned in this Paper

Cell Secretion
Blood Pressure
Deficiency Diseases
Renin Measurement
Prostaglandin E2 Measurement
Paper Details
References
  • References35
  • Citations21
1234
  • References35
  • Citations21
123

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