Evidence of recurrent autoimmunity in human allogeneic islet transplantation

Transplantation
M D StegallR G Gill

Abstract

We transplanted 10,000 isolated, handpicked human pancreatic islets into the subfascial compartment of the forearm muscle of a type I diabetic recipient who had received a successful renal transplant one year prior. The recipient was maintained on his usual immunosuppressive therapy of cyclosporine, azathioprine, and prednisone. A biopsy performed 7 days after transplantation showed normal islets with both insulin- and glucagon-staining cells present and no lymphocytic infiltration. A second biopsy performed 14 days after transplantation showed a dense mononuclear cell infiltrate with a preferential loss of insulin-staining cells relative to glucagon-staining cells in the islets. These data are consistent with recurrent autoimmune diabetes in an isolated islet allograft in an immunosuppressed type I diabetic recipient. In addition, this forearm subfascial site may be a useful means to monitor islet rejection and autoimmune recurrence in therapeutic intraportal islet allografts.

References

Jan 1, 1989·Diabetes·D E SutherlandR K Sibley
Nov 1, 1986·The Journal of Clinical Investigation·R AlejandroD H Mintz
Apr 1, 1988·Diabetes·C RicordiD W Scharp

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Citations

Nov 5, 1997·Diabetologia·N M DesaiK J Lafferty
Oct 11, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Natasha A DetersJenny E Gunton
Mar 29, 2011·Der Pathologe·C LacknerH Nizze
Jul 27, 2011·Current Diabetes Reports·Elisa Cantarelli, Lorenzo Piemonti
Jun 29, 2000·Trends in Pharmacological Sciences·C J Bailey
Mar 17, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·S A WhiteM L Nicholson
Sep 19, 1996·The New England Journal of Medicine·G S Eisenbarth, M Stegall
Sep 29, 2006·The New England Journal of Medicine·UNKNOWN Worcester Human Islet Transplantation GroupA A Rossini
Mar 20, 2009·Transplantation·David A BaidalRodolfo Alejandro
Dec 10, 2009·Transplantation·Christian TosoA M James Shapiro
Oct 21, 2011·Journal of Transplantation·Ping WangAnna Moore
Sep 13, 2012·Journal of Transplantation·Emily Sims, Carmella Evans-Molina
Feb 21, 2002·Journal of Biomaterials Science. Polymer Edition·M V Risbud, R R Bhonde
Dec 10, 2003·Journal of Biomaterials Science. Polymer Edition·Laurence KesslerAlain Belcourt
Feb 23, 2012·Endocrinology·Chengyang LiuMichael R Rickels
Sep 20, 2011·Diabetes Management·Alberto PuglieseGeorge W Burke
Apr 27, 2010·Advances in Anatomic Pathology·Deepa T Patil, Lisa M Yerian
Jun 22, 2005·Treatments in Endocrinology·Daniel M RidgwayRachel M Kimber
Apr 13, 2010·Expert Review of Clinical Immunology·Jamil AzziReza Abdi
Jul 28, 2011·Expert Review of Clinical Immunology·Rainer W G GruessnerGeorge W Burke
Sep 25, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mohammed Javeed I AnsariMohamed H Sayegh
Aug 12, 2004·Xenotransplantation·Lijun BaiBernard E Tuch
Jun 5, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James Neuberger
Jul 2, 2003·Journal of Biomedical Materials Research. Part a·Makarand V RisbudRamesh R Bhonde
Dec 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E RafaelJ Permert
Feb 13, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y D MullerT Berney
Mar 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SterkersF Pattou
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q ShiS T Bartlett
Dec 14, 2004·Biochemical Pharmacology·Zandong YangJerry L Nadler
Dec 29, 2004·Transplantation Proceedings·J D CarterZ Yang
Mar 31, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nicoletta FotinoAntonello Pileggi
Sep 8, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·J Neuberger
Nov 7, 1999·Journal of Autoimmunity·S M DiltsK J Lafferty

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