Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue

Neuroreport
G E KisbyC Sweatt

Abstract

Oxidative stress is proposed to play a central role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Anti-oxidant enzymes and DNA repair proteins are two major mechanisms by which cells counteract the deleterious effects of reactive oxygen species (ROS). Neurons may be particularly vulnerable to ROS-induced oxidative DNA damage; this is repaired by the base-excision repair (BER) pathway. Frontal cortical levels and activity of the pivotal BER protein apurinic/apyrimidinic endonuclease (APE) were determined in 11 patients with sporadic ALS and six age-matched control subjects. APE levels (p < 0.003) and activity (p < 0.000007) were significantly lower in ALS subjects than in controls. These findings suggest that ALS brain tissue is inefficient in repairing oxidative DNA damage.

References

Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Nov 1, 1982·Archives of Neurology·W G Bradley, F Krasin
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·S XanthoudakisT Curran
May 1, 1995·Journal of the Neurological Sciences·C Bergeron
May 1, 1993·Mutation Research·J Tchou, A P Grollman
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P Rowland
Jan 1, 1994·Annual Review of Biochemistry·B Demple, L Harrison
Apr 1, 1993·Journal of the Neurological Sciences·S H RobisonW G Bradley
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·A Wallin, K Blennow

❮ Previous
Next ❯

Citations

Apr 27, 2001·Toxicology Letters·M C MillerD A Bell
Oct 6, 2000·Mutation Research·A R EvansM R Kelley
Dec 6, 2011·The Journal of Biological Chemistry·Alessio CardinaleDaniela Merlo
Feb 21, 2006·Antioxidants & Redox Signaling·Judith A Potashkin, Gloria E Meredith
Nov 23, 2006·Antioxidants & Redox Signaling·Ari Barzilai
Nov 4, 2008·Carcinogenesis·Scott MaynardVilhelm A Bohr
Oct 12, 2000·Nucleic Acids Research·M Z HadiD M Wilson
Jul 23, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sebastiano La MaestraSilvio De Flora
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M FujimuraP H Chan
Nov 30, 2011·TheScientificWorldJournal·Fabio Coppedè
Jan 10, 2013·PloS One·Claudia Figueroa-RomeroEva L Feldman
Jul 1, 1997·Reviews in the Neurosciences·M DragunowR L Faull
Dec 4, 2012·International Journal of Molecular Sciences·Matthias BosshardBarbara van Loon
Jul 10, 2013·Antioxidants & Redox Signaling·Mengxia Li, David M Wilson
Aug 26, 1999·Drug Metabolism Reviews·G E KisbyP Spencer
Aug 27, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Fabio CoppedèLucia Migliore
Oct 16, 2012·Progress in Neurobiology·Rory JohnsonNoel J Buckley
May 10, 2011·Progress in Neurobiology·Dennis Kjølhede JeppesenTinna Stevnsner
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel
Apr 22, 2008·Mechanisms of Ageing and Development·Guogang XuChristi A Walter
Feb 26, 2008·Neurobiology of Disease·Stuart G JarrettManisha Patel
May 29, 2007·Neuroscience Letters·Fabio CoppedèGabriele Siciliano
Aug 2, 2006·Mutation Research·Melissa L FishelMark R Kelley
Mar 13, 2003·Clinical Genetics·D Majoor-KrakauerA Hofman
Aug 29, 2006·Neuroscience·D M Wilson, D R McNeill
Nov 10, 2006·Neuroscience·L WeissmanV A Bohr
Mar 1, 2006·Biochimica Et Biophysica Acta·Francois Gros-LouisGuy A Rouleau
Nov 17, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mi-Young KangMi-Hwa Kim
Sep 23, 2014·Oxidative Medicine and Cellular Longevity·Jae Sung ParkYoung Rok Seo
Sep 14, 2019·PloS One·Marcin RadomPiotr Formanowicz
Aug 25, 2019·Molecular Psychiatry·Karl GrenierPhedias Diamandis
Feb 16, 1999·Brain Pathology·M R Cookson, P J Shaw
Apr 27, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J CuiP K Liu

❮ Previous
Next ❯

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