Evidence of SARS-CoV-2 Infection in Cells, Tissues, and Organs and the Risk of Transmission Through Transplantation.

Transplantation
Amaury GaussenAntoine Lewin

Abstract

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible for the coronavirus disease 2019 (COVID-19) pandemic has raised concerns for programs overseeing donation and transplantation of cells, tissues, and organs (CTO) that this virus might be transmissible by transfusion or transplantation. Transplant recipients are considered particularly vulnerable to pathogens because of immunosuppression, and SARS-CoV-2 is likely to generate complications if contracted. Several signs and symptoms observed in COVID-19 positive patients reflect damage to multiple organs and tissues, raising the possibility of extrapulmonary SARS-CoV-2 infections and risk of transmission. At the beginning of the pandemic, a consensus has emerged not to consider COVID-19 positive patients as potential living or deceased donors, resulting in a global decrease in transplantation procedures. Medical decision-making at the time of organ allocation must consider safely alongside the survival advantages offered by transplantation. To address the risk of transmission by transplantation, this review summarizes the published cases of transplantation of cells or organs from donors infected with SARS-CoV-2 until January 2021 and...Continue Reading

References

Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Mar 20, 2004·Emerging Infectious Diseases·Kwok H ChanJoseph S Malik Peiris
Mar 25, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D XuF S Wang
Jul 27, 2005·The Journal of Experimental Medicine·Jiang GuAnthony S-Y Leong
Jun 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hung-Yi Wu, David A Brian
Jul 21, 2017·Gastroenterology Research·Prashanth RawlaAnantha R Vellipuram
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 15, 2020·JAMA : the Journal of the American Medical Association·Min WeiZhi-Jiang Zhang
Feb 20, 2020·The New England Journal of Medicine·Lirong ZouJie Wu
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 23, 2020·JAMA : the Journal of the American Medical Association·Yan BaiMeiyun Wang
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Feb 23, 2020·The Lancet Infectious Diseases·Xingfei PanJing Liu
Feb 25, 2020·Emerging Infectious Diseases·Zhen-Dong TongJian-Bo Yan
Feb 29, 2020·Transfusion Medicine Reviews·Le ChangLunan Wang
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kai-Qian KamKoh Cheng Thoon
Mar 10, 2020·Emerging Infectious Diseases·An TangJian-Bo Yan
Mar 23, 2020·Biochemical and Biophysical Research Communications·Furong QiZheng Zhang
Jan 1, 2012·Cytology and Genetics·A HashemiA Memarnejadian
Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
Apr 3, 2020·Vox Sanguinis·So-Yong KwonNam-Sun Cho
Apr 4, 2020·Transplantation·C AhnG Wong
Apr 11, 2020·European Journal of Heart Failure·Guido TavazziEloisa Arbustini
Apr 11, 2020·American Journal of Clinical Pathology·Lisa M BartonSanjay Mukhopadhyay
Apr 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sufang TianShu-Yuan Xiao
Apr 16, 2020·European Heart Journal·Luka NicinStefanie Dimmeler
Apr 18, 2020·Archives of Pathology & Laboratory Medicine·Stephen M LaganaJay H Lefkowitch
Apr 18, 2020·Annals of Internal Medicine·Francesca ColavitaConcetta Castilletti
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network

❮ Previous
Next ❯

Citations

Jul 14, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christine E KovalAlvin Wee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Christine E KovalAlvin Wee
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Olivia S KatesAjit P Limaye
Emerging Infectious Diseases
Roosecelis B MartinesCOVID-19 Pathology Working Group
Nature Reviews. Microbiology
Ben HuZheng-Li Shi
© 2021 Meta ULC. All rights reserved