Evidence of sociodemographic heterogeneity across the HIV treatment cascade and progress towards 90-90-90 in sub-Saharan Africa - a systematic review and meta-analysis

Journal of the International AIDS Society
Dylan GreenPaul K Drain

Abstract

Heterogeneity of sociodemographics and risk behaviours across the HIV treatment cascade could influence the public health impact of universal ART in sub-Saharan Africa if those not virologically suppressed are more likely to be part of a risk group contributing to onward infections. Sociodemographic and risk heterogeneity across the treatment cascade has not yet been comprehensively described or quantified and we seek to systematically review and synthesize research on this topic among adults in Africa. We conducted a systematic review of peer-reviewed literature in Embase and MEDLINE databases as well as grey literature sources published in English between 2014 and 2018. We included studies that included people living with HIV (PLHIV) aged ≥15 years, and reported a 90-90-90 outcome: awareness of HIV-positive status, ART use among those diagnosed or viral suppression among those on ART. We summarized measures of association between sociodemographics, within each outcome, and as a composite measure of population-wide viral suppression. From 3533 screened titles, we extracted data from 92 studies (50 peer-reviewed, 42 grey sources). Of included studies, 32 reported on awareness, 53 on ART use, 32 on viral suppression and 23 on po...Continue Reading

References

Sep 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mirjam E KretzschmarRoel A Coutinho
Feb 28, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Man E CharuratUNKNOWN TRUST Study Group
Mar 19, 2016·The International Journal on Drug Policy·Kathryn E LancasterWilliam C Miller
Oct 14, 2016·BMJ : British Medical Journal·Jonathan Ac SterneJulian Pt Higgins

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Citations

Jun 15, 2020·Journal of the International AIDS Society·Jonathan RossUNKNOWN Central Africa IeDEA
Apr 4, 2021·International Journal of Environmental Research and Public Health·Emmanuel PeprahAndre Pascal Kengne
Nov 21, 2020·The Lancet. Gastroenterology & Hepatology·Fengyi JinAndrew E Grulich

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