Evidence of the bioaccumulation of ciguatoxins in giant clams (Tridacna maxima) exposed to Gambierdiscus spp. cells

Harmful Algae
Mélanie RouéM Chinain

Abstract

Ciguatera Fish Poisoning (CFP) is a foodborne disease classically related to the consumption of tropical coral reef fishes contaminated with ciguatoxins (CTXs), neurotoxins produced by dinoflagellates of the Gambierdiscus genus. Severe atypical ciguatera-like incidents involving giant clams, a marine resource highly consumed in the South Pacific, are also frequently reported in many Pacific Islands Countries and Territories. The present study was designed to assess the ability of giant clams to accumulate CTXs in their tissues and highlight the potential health risks associated with their consumption. Since giant clams are likely to be exposed to both free-swimming Gambierdiscus cells and dissolved CTXs in natural environment, ex situ contamination experiments were conducted as follows: giant clams were exposed to live or lyzed cells of TB92, a highly toxic strain of G. polynesiensis containing 5.83±0.85pg P-CTX-3C equiv.cell-1vs. HIT0, a weakly toxic strain of G. toxicus containing only (2.05±1.16)×10-3pg P-CTX-3C equiv.cell-1, administered over a 48h period at a concentration of 150cellsmL-1. The presence of CTXs in giant clams tissues was further assessed using the mouse neuroblastoma cell-based assay (CBA-N2a). Results show...Continue Reading

Citations

May 29, 2020·Critical Reviews in Food Science and Nutrition·Matheus Lopes AmorimMarcio Arêdes Martins
Dec 14, 2017·Environmental Science and Pollution Research International·Chang TianWenrong Hu
Jul 11, 2020·Scientific Reports·Li Keat LeePo Teen Lim
Feb 15, 2020·Harmful Algae·Patricia A TesterElisa Berdalet
Feb 20, 2021·Journal of Invertebrate Pathology·Andrew D TurnerBenjamin H Maskrey
Aug 10, 2020·Ecotoxicology and Environmental Safety·G GaianiM Campàs
Sep 5, 2021·Environmental Science and Pollution Research International·Raquel A F NevesLuciano N Santos

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