Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model

Journal of Neuroinflammation
Chunxia HuangRaymond Chuen Chung Chang

Abstract

Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without any pathogen, to characterize these changes and their responses to anti-inflammatory treatment in the intermediate term. In a two-part experiment, wild-type C57BL/6N mice (male, 3 month old, 25 ± 2 g) were subjected to sevoflurane anesthesia alone or to a laparotomy. Cognitive performance, systemic and neuroinflammatory responses, and tau phosphorylation were evaluated on postoperative days (POD) 1, 3, and 14. The effect of perioperative ibuprofen intervention (60 mg/kg) on these changes was then assessed. Mice in the laparotomy group displayed memory impairment up to POD 14 with initial high levels of inflammatory cytokines in the liver, frontal cortex (IL-1β, IL-6, and TNF-α), and hippocampus (IL-1β and IL-8). On POD 14, although most circulating and resident cytokine levels returned to normal, a significant number of microglia and astrocytes remained activated in the frontal cortex and microglia in the hippocampus, as well as abnormal tau phosphorylation in these two brain regions. Perioperative ibuprofen improved cogni...Continue Reading

References

Mar 26, 2003·Anesthesia and Analgesia·Deborah J CulleyGregory Crosby
Sep 29, 2004·Trends in Biochemical Sciences·Gerard Drewes
Jan 13, 2006·The Journal of Cell Biology·Dominic Chi Hiung NgXinmin Cao
Apr 2, 2008·Neurobiology of Aging·Alie SchuitemakerCees Jonker
May 2, 2008·Progress in Neurobiology·Jian-Zhi Wang, Fei Liu
Jan 17, 2009·Reviews in the Neurosciences·Suzan Dziennis, Nabil J Alkayed
Jan 5, 2011·Nature Reviews. Neuroscience·Lars M Ittner, Jürgen Götz
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tijana CopfThomas Preat
Aug 23, 2011·Anesthesiology·Junxia X TangRoderic G Eckenhoff
Jan 31, 2012·Neuron·Céline S NicolasGraham L Collingridge
Jun 5, 2013·Annals of Surgery·Zhongcong XieEdward R Marcantonio
Jul 23, 2013·Anesthesiology·Inge K HerrmannBeatrice Beck-Schimmer
Aug 7, 2013·Experimental Gerontology·Iris B HovensBarbara L van Leeuwen
Aug 15, 2013·Brain : a Journal of Neurology·Elina ZotovaDelphine Boche
Nov 23, 2013·Nature Protocols·Marianne LegerThomas Freret
Feb 13, 2014·Brain, Behavior, and Immunity·Iris B HovensBarbara L van Leeuwen
Dec 3, 2014·Neurobiology of Learning and Memory·Iris B HovensRegien G Schoemaker
Feb 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lucile Ben HaimCarole Escartin
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
May 21, 2015·Nature Reviews. Neuroscience·Philip TovoteAndreas Lüthi
Jun 7, 2015·Journal of Neuroinflammation·Inge C M HooglandDiederik van de Beek
Nov 21, 2015·Journal of Neuroinflammation·David Chun-Hei PoonRaymond Chuen-Chung Chang
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Chunxia HuangGordon Tin-Chun Wong
Jun 21, 2016·Nature Neuroscience·Jessica W WuKaren E Duff

❮ Previous
Next ❯

Citations

May 17, 2019·Cellular and Molecular Life Sciences : CMLS·Rashmi Das, Subashchandrabose Chinnathambi
Oct 1, 2019·Epidemiologic Reviews·Sorayya Kheirouri, Mohammad Alizadeh
Oct 28, 2019·International Journal of Molecular Sciences·Anjana AjikumarJulie E Simpson
Jun 4, 2019·Journal of Neuroinflammation·Sara HemmatiAhmad Reza Dehpour
Sep 26, 2020·Frontiers in Cellular Neuroscience·Wenguo FanHongwen He
Mar 15, 2020·Journal of Molecular Neuroscience : MN·Yu-Han ChungHsiu Mei Hsieh-Li
Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Yuen-Shan HoRaymond Chuen-Chung Chang
Dec 2, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yong ZuoZhenhua Shi
Jan 11, 2021·Brain Research Bulletin·Yuen-Shan HoRaymond Chuen-Chung Chang
Jul 10, 2021·Journal of Neuroinflammation·Klaske ObermanRegien Schoemaker
Jul 27, 2021·Frontiers in Aging Neuroscience·Cong-Mei WangHe-Fan He
Aug 17, 2020·British Journal of Anaesthesia·Zhaosheng JinDaqing Ma
Sep 11, 2020·Brain Research Bulletin·Xiang FeiZhi-Yong Sheng

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Image
Graph Pad
ZEN
GraphPad Prism

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here