Evidence of the mechanism of action of Erythrina velutina Willd (Fabaceae) leaves aqueous extract

Journal of Ethnopharmacology
Ana Carla C S CarvalhoRosilene Moretti Marçal

Abstract

Erythrina velutina is traditionally used for sleepiness, convulsions and nervous system excitation in Brazil. Although central effects have been reported for Erythrina velutina, little is known about its mechanism of action. To investigate the pharmacological evidences of mechanism of action of Erythrina velutina leaves aqueous extract (AE). Terminal segments of the guinea-pig ileum (n=5-8) were mounted in an organ bath and isotonic contractions were recorded. Phytochemical screening was carried out on AE. AE (0.025-2.50 mg/ml) produced contractile response in the guinea-pig ileum, yielding typical concentration-response curves (EC50=0.63 mg/ml). Electrically evoked contractions were significantly increased in the presence of AE. AE-elicited contractions were significantly reduced by bicuculline, tetrodotoxin, atropine, verapamil or incubation in low calcium-high potassium solution. Atropine along with verapamil abolished AE contractile response. Alkaloids, catechins, steroids, flavonols, flavononols, flavonoids, phenols, saponins, tannins, triterpenoids, and xanthones were detected in AE. AE contains important constituents for pharmacological activities. AE-induced contractions seem to involve GABAA receptor activation, acetyl...Continue Reading

References

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Jul 5, 2003·Biological & Pharmaceutical Bulletin·Silvânia Maria Mendes VasconcelosGlauce Socorro Barros Viana
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Oct 31, 2006·Journal of Ethnopharmacology·Silvânia M M VasconcelosGlauce Socorro B Viana

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Citations

Oct 30, 2012·Fitoterapia·Fábia Valéria M SouzaRosilene Moretti Marçal
May 8, 2013·The Journal of Pharmacy and Pharmacology·Amilton Gustavo da Silva PassosCarla Maria Lins de Vasconcelos
May 26, 2012·Fitoterapia·Marcelly Barbosa da RochaRosilene Moretti Marçal
Oct 14, 2018·Journal of Complementary & Integrative Medicine·Naiara Coelho XimenesSilvânia Maria Mendes Vasconcelos
Feb 16, 2019·Phytotherapy Research : PTR·Douglas F RamboAmélia T Henriques

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