Evidence of the presence in normal serum of a carrier of the serum thymic factor (FTS)

European Journal of Immunology
M DardenneJ F Bach

Abstract

Chromatography of normal human or mouse serum on Sephadex G-150 revealed the presence of two peaks of activity in the rosette assay used for the characterization of the serum thymic factor (FTS). One peak corresponded to the elution volume of FTS (mol. wt. 867), the other to molecules with mol. wts. of 40 000-60 000. Both peaks were absent in serum of thymectomized (Tx) mice but could be induced in such Tx mice by injection of synthetic FTS. Study of the biological half-life of both peaks (assessed by the rosette assay) and demonstration of their specific retention on anti-FTS immunosorbent indicate, altogether with direct binding experiments, that FTS is transported in serum by a molecule with a mol. wt. of the order of that of albumin or prealbumin. It is apparent that FTS bound to this molecule is responsible for the biological FTS-like activity associated with large mol. wt. fractions of normal serum.

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P M BurtonA White
Nov 18, 1972·Lancet·J F BachH Le Brigand
Sep 1, 1974·FEBS Letters·P De la LlosaM P De la Llosa-Hermier

Citations

May 1, 1992·Brain Research. Brain Research Reviews·C NilssonC Owman
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Joana Almeida Palha
Jul 14, 1987·Biochemistry·T PetterssonH Jörnvall

Related Concepts

Carrier Proteins
Molecular Sieve Chromatography
Half-Life
Immunosorbents
Mice, Inbred C57BL
Prealbumin
Immunocytoadherence
Dall Sheep
Thymic Factor, Circulating
Thymus Hormones

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