Evidence of the selective alteration of anthracycline activity due to modulation by ICRF-187 (ADR-529)

Pharmacology & Therapeutics
M D GreenJ L Speyer

Abstract

Anthracyclines are powerful anticancer drugs whose use is limited by the development of chronic cardiotoxicity. The bisdioxopiperazine compound ICRF-187 (ADR-529) specifically abrogates this toxicity both in preclinical animal models and in humans. It does this without effecting either the acute toxicities or the anticancer activity. Therefore, with a specific antagonist, the mechanism of activity of the anthracyclines can be explored. This review discusses recent clinical trials and animal models addressing this issue and concludes by hypothesizing a mechanism of action.

References

Oct 1, 1979·Journal of Molecular and Cellular Cardiology·P J BoorW C Roberts
Oct 1, 1978·Journal of Molecular and Cellular Cardiology·N W Revis, N Marusic
Nov 1, 1976·Journal of the National Cancer Institute·C C Bier, R S Jaenke
Jun 12, 1985·Biochimica Et Biophysica Acta·G Daum
Apr 1, 1986·The Journal of Pharmacy and Pharmacology·R H JulicherJ Noordhoek
Sep 25, 1986·Biochimica Et Biophysica Acta·E GoormaghtighJ M Ruysschaert
Dec 1, 1987·Cancer Treatment Reviews·E H Herman, V J Ferrans
Jun 16, 1986·Biochimica Et Biophysica Acta·K NicolayB de Kruijff
Feb 17, 1986·FEBS Letters·E J Demant, N Nørskov-Lauritsen
Oct 1, 1985·Journal of Applied Physiology·M M KanterA J Merola
Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
May 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·E H HermanV S Waravdekar
Mar 29, 1969·British Medical Journal·K HellmannJ V Bond
Apr 26, 1969·Nature·A M CreightonS Whitecross
Feb 1, 1983·Journal of Pharmacobio-dynamics·T AdachiM Sugiura
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Aug 1, 1984·European Journal of Biochemistry·E J Demant
Dec 5, 1984·Biochimica Et Biophysica Acta·K NicolayB De Kruijff
Oct 1, 1982·British Journal of Cancer·W E PerkinsA R Imondi
Jan 1, 1982·Advances in Pharmacology and Chemotherapy·E H HermanV S Waravdekar
Feb 1, 1982·Annals of Internal Medicine·S S LeghaE J Freireich
Sep 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P M MayD R Williams
Jun 1, 1981·British Journal of Cancer·G WangK Hellmann
Mar 27, 1980·Biochimica Et Biophysica Acta·E GoormaghtighJ M Ruysschaert
Nov 1, 1980·Biochemical Pharmacology·E GoormaghtighJ M Ruysschaert

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Citations

Sep 28, 1998·Biochimica Et Biophysica Acta·T Andoh, R Ishida
Aug 1, 1995·British Journal of Pharmacology·S A van AckerA Bast
Oct 26, 1999·BMJ : British Medical Journal·K Hellmann
Dec 1, 1993·British Heart Journal·W RhodenN Brooks
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·B C HüskenA Bast
Jul 5, 2005·Free Radical Biology & Medicine·Eileen M HokeEmily Shacter
Mar 3, 1998·Blood Reviews·D S Richardson, S A Johnson
Jan 21, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MartyUNKNOWN Dexrazoxane Study Group

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