Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen

Clinical Neurology and Neurosurgery
Jørgen Feldbaek NielsenJens Just Christensen

Abstract

In a retrospective study, changes in baclofen dose and complication frequency were recorded in 79 patients with intrathecal baclofen administration and the effect on nightly muscle spasms was measured over a mean observation period of 34 months, during which time an increase in the daily dose of baclofen during the first 1--1-1/2 years is notified. On subsequent pump fillings the daily dose of baclofen remained stable in the group of non-multiple sclerosis patients. In contrast, the group of multiple sclerosis patients showed a steady increase in their daily dose of baclofen. We found a frequency of complications of 0.014 monthly often due to catheter problems. There was a significant decrease in numbers of nightly muscle spasms in an 8 h recording period from 77+/-20 preoperatively and 9+/-3 (P=0.02) 3 months after surgery. The steady increase in the daily dose of baclofen in order to obtain adequate reduction in spasticity and nightly muscle spasms in the first 1--1-1/2 years cannot fully be explained by caution and difficulties in achieving the correct dose, but also indicates that tolerance to baclofen occurs. Complications are often due to infection or catheter problems.

References

Dec 1, 1992·American Journal of Physical Medicine & Rehabilitation·J M MeythalerC S Haworth
Aug 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·G OchsP Weinmann
Jun 8, 1989·The New England Journal of Medicine·R D PennJ S Kroin
Sep 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·R A MacdonellD Grundy
Jul 20, 1985·Lancet·R D Penn, J S Kroin
Feb 1, 1989·Experimental Neurology·M L LatashG L Gottlieb
Feb 1, 1987·Journal of Neurosurgery·R D Penn, J S Kroin
May 12, 1984·Lancet·R D Penn, J S Kroin
Aug 1, 1993·Paraplegia·M N AkmanC D Rossi
May 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P AzouviB Bussel
Sep 1, 1996·Journal of Neurosurgery·M Winkelmüller, W Winkelmüller
Apr 26, 2006·Spinal Cord·F Biering-SørensenK Klinge

❮ Previous
Next ❯

Citations

Nov 10, 2012·Drugs & Aging·Abdel Magid O Bakheit
Dec 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Masaji MurakamiJun-ichi Kuratsu
Jun 4, 2011·The Journal of Pharmacology and Experimental Therapeutics·Laura K K PaceyDavid R Hampson
Jan 11, 2014·Journal of Neurosurgery. Pediatrics·Francesco Motta, Clara E Antonello
Jan 11, 2014·Archives of Physical Medicine and Rehabilitation·Léo BorriniClaire Jourdan
Jun 4, 2014·Archives of Physical Medicine and Rehabilitation·Herre W HeetlaTeus van Laar
Jul 24, 2014·Disability and Rehabilitation·Stina Gunnarsson, Kersti Samuelsson
Oct 17, 2002·The Journal of Physiology·Jonathon P Wetherington, Nevin A Lambert
Oct 31, 2015·Journal of Neurosurgery. Pediatrics·Charlotte SayerMargaret Kaminska
Nov 4, 2006·Topics in Stroke Rehabilitation·Gerard E FranciscoSamuel Grissom
Dec 18, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Takaomi TairaHirokazu Tanabe
Oct 30, 2014·Basic & Clinical Pharmacology & Toxicology·Louise Bendix KielKim Peder Dalhoff
Aug 26, 2014·The Spine Journal : Official Journal of the North American Spine Society·Alexandra KisuckáNadežda Lukáčová
Mar 5, 2016·Trends in Pharmacological Sciences·Anton BespalovThomas Hudzik
Nov 5, 2003·Annals of Plastic Surgery·Sarah A MessFred Heckler
Jul 17, 2018·Journal of Child Neurology·Gidon WinterHilla Ben-Pazi
Apr 24, 2007·American Journal of Physical Medicine & Rehabilitation·Shearwood McClellandNicholas M Boulis
Dec 15, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Olivier Ameisen
Apr 20, 2010·The Journal of Spinal Cord Medicine·April Saval, Anthony E Chiodo
Dec 12, 2012·Journal of Neurophysiology·Jessica M D'AmicoMonica A Gorassini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.