Abstract
Endothelial infection has an important role in the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF). In this study, we investigated the causes of vascular endothelial damage in patients with CCHF. This prospective case-controlled study was carried out at Ankara Numune Education and Research Hospital between April and September 2007. Seventy-five patients with a laboratory-confirmed diagnosis of CCHF and 88 healthy controls were enrolled in the study. Serum levels of soluble cell adhesion molecules (sICAM-1, sVCAM-1, sE-selectin, sP-selectin, sL-selectin), vascular endothelial growth factor (VEGF), and macrophage migration inhibitory factor (MIF) were investigated in these patients by quantitative sandwich ELISA technique. In the patient group, serum levels of sVCAM-1, sL-selectin and MIF were significantly higher than in the control group; serum levels of sICAM-1, sP-selectin, sE-selectin, and VEGF were significantly lower than in the control group. Serum levels of sVCAM-1 and sICAM-1 were significantly higher in severe cases than in non-severe cases, whereas the serum level of VEGF was significantly lower. sVCAM-1 was significantly higher in non-survivors than in survivors, while serum VEGF was significantly lower in non...Continue Reading
References
Jan 1, 1994·Annual Review of Medicine·M P BevilacquaO Cecconi
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
Apr 30, 1998·Journal of Virological Methods·F J BurtR Swanepoel
Sep 6, 2001·Intensive Care Medicine·S GandoO Kemmotsu
Mar 14, 2002·Critical Care Medicine·John A. Baugh, Richard Bucala
Jan 30, 2004·Journal of Medical Virology·Penelopie KorakaJan Groen
Sep 21, 2004·Shock·Fernando A BozzaMarcelo T Bozza
Oct 22, 2004·Emerging Infectious Diseases·S Sami KartiThomas G Ksiazek
Nov 20, 2004·Antiviral Research·Chris A Whitehouse
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R N CharrelX de Lamballerie
Dec 21, 2004·FEMS Immunology and Medical Microbiology·Chien-Sen TsengChen-Guo Ker
Mar 17, 2005·Journal of Medical Microbiology·Mehmet BakirUNKNOWN Turkish CCHF Study Group
Jun 13, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna PapaAntonis Antoniadis
Nov 9, 2006·Endothelium : Journal of Endothelial Cell Research·José E CardierRoberto Giovannetti
Dec 8, 2006·Journal of Virology·Anon SrikiatkhachornAlan L Rothman
Aug 25, 2007·Annals of Tropical Paediatrics·Patcharapa SathupanYong Poovorawan
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mustafa Aydin CevikAyhan Kubar
Dec 8, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mustafa A CevikEsragül Akinci
Apr 19, 2008·The Journal of Infection·Pinar OnguruMustafa Aydin Cevik
Nov 26, 2008·Cytokine & Growth Factor Reviews·Friedemann Weber, Ali Mirazimi
Dec 30, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Esragül AkinciGülsüm Ozet
Citations
May 15, 2013·Vector Borne and Zoonotic Diseases·Esragül AkıncıHakan Leblebicioglu
Jun 3, 2011·Journal of Virology·Anne-Marie Connolly-AndersenAli Mirazimi
Apr 10, 2014·PloS One·Lidia Lasecka, Michael D Baron
Apr 14, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mehmet ArasliMehmet Ceyhan
Jul 23, 2015·Laboratory Medicine·Sara ShayanSadegh Chinikar
Jun 6, 2015·Thrombosis Research·Hidekatsu TazawaRitsuko Ohtani-Kaneko
Apr 29, 2011·International Journal of Pediatric Otorhinolaryngology·İsmail Önder UysalSuphi Müderris
Jun 30, 2015·Journal of Medical Virology·Anna PapaGulay Korukluoglu
Jul 23, 2013·Journal of Medical Virology·Mehmet BakirAynur Engin
Feb 5, 2015·Journal of Medical Virology·Anna PapaYavuz Uyar
Jan 30, 2013·Renal Failure·Mevlut Ceri
Jun 15, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kenan Ahmet TurkdoganMehmet Birhan Yilmaz
Aug 3, 2013·Antiviral Research·Dennis A BenteMike Bray
Dec 23, 2014·Emerging Infectious Diseases·Nicholas G CongerMark G Kortepeter
Jul 6, 2016·Antiviral Research·Esragul AkinciHakan Leblebicioglu
Nov 1, 2016·Iranian Red Crescent Medical Journal·Laila Mohamed Al DabalAbid Mustafa Alwan
Mar 3, 2017·Japanese Journal of Infectious Diseases·Seyit Ali BüyüktunaSevtap Bakır
Jul 3, 2018·Japanese Journal of Infectious Diseases·Fazilet DuyguFeyza Aytekin
Aug 6, 2013·Virologica Sinica·Serkan Oncü
Apr 7, 2020·PLoS Neglected Tropical Diseases·Robert A KozakGary P Kobinger
Aug 14, 2020·PLoS Neglected Tropical Diseases·Robert W CrossThomas W Geisbert
Apr 2, 2015·The Pediatric Infectious Disease Journal·Enver SancakdarEsra Gültürk
Mar 13, 2015·The Pediatric Infectious Disease Journal·Hekim KarapinarAhmet Yilmaz
Nov 10, 2011·Scandinavian Journal of Infectious Diseases·Serdal Arslan, Aynur Engin
Jan 24, 2014·Japanese Journal of Infectious Diseases·Eda Karadag-OncelMehmet Ceyhan
Jun 13, 2017·Frontiers in Cellular and Infection Microbiology·Anna PapaAli Mirazimi
Jun 20, 2017·Journal of Medical Virology·Mustafa ArslanIftihar Koksal
Nov 22, 2017·Archives of Virology·Halef Okan DoğanSevtap Bakir
Nov 25, 2020·PLoS Neglected Tropical Diseases·Vanessa MonteilAli Mirazimi