Evidence of vasopressinergic-noradrenergic mechanisms in depression with above-normal plasma vasopressin concentration with and without psychotic features

Journal of Psychopharmacology
J G GoekoopV M Wiegant

Abstract

Previous studies in the field of melancholic or endogenous depression have resulted in support for a subcategory of depression with above-normal plasma vasopressin (AVP) concentration (ANA). Since an analogous animal model with increased release of above-normal plasma vasopressin exhibits reduced Sympathetic-Nervous-System activity, the present study investigated the plasma norepinephrine concentration and the correlation between plasma norepinephrine and AVP in this ANA depression. As psychotic-melancholic patients may have increased plasma norepinephrine concentration, and noradrenergic activation may stimulate AVP release, potentially confounding effects of psychotic features were also investigated. The data set of the same depressed patient sample that was used before, but limited to those with complete hormonal data (n = 75), was re-analysed. ANA depression (n = 14) had negatively correlating AVP and norepinephrine concentrations. A very small subcategory of ANA depression with psychotic features (n = 3) had high plasma norepinephrine concentration, suggesting that this could be an independent subcategory. This was supported by the combination of relatively low above-normal plasma AVP concentrations with the highest severi...Continue Reading

References

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Citations

Dec 29, 2011·Depression Research and Treatment·Jaap G Goekoop, Remco F P De Winter
Apr 12, 2013·Journal of Neuroendocrinology·S M KagerbauerR Landgraf
Apr 1, 2012·Therapeutic Advances in Psychopharmacology·Jaap G GoekoopVictor M Wiegant
Sep 12, 2020·Pharmacological Reviews·C Sue CarterMarcy A Kingsbury

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