Evidence on clinical relevance of cardiovascular risk evaluation in the general population using cardio-specific biomarkers.

Clinical Chemistry and Laboratory Medicine : CCLM
Aldo ClericoMario Plebani

Abstract

In recent years, the formulation of some immunoassays with high-sensitivity analytical performance allowed the accurate measurement of cardiac troponin I (cTnI) and T (cTnT) levels in reference subjects. Several studies have demonstrated the association between the risk of major cardiovascular events and cardiac troponin concentrations even for biomarker values within the reference intervals. High-sensitivity cTnI and cTnT methods (hs-cTn) enable to monitor myocardial renewal and remodelling, and to promptly identify patients at highest risk ofheart failure. An early and effective treatment of individuals at higher cardiovascular risk may revert the initial myocardial remodelling and slow down heart failure progression. Specific clinical trials should be carried out to demonstrate the efficacy and efficiency of the general population screening by means of cost-benefit analysis, in order to better identify individuals at higher risk for heart failure (HF) progression with hs-cTn methods.

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Citations

Jan 15, 2021·European Journal of Heart Failure·Navin SuthaharRudolf A de Boer
May 21, 2021·Expert Review of Molecular Diagnostics·Feven Ataklte, Ramachandran S Vasan
Aug 8, 2021·Journal of Clinical Medicine·Shruti Rajesh PatelKathryn J Ruddy
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani
Jul 6, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani

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