Evidence suggesting a transmitter or neuromodulatory role for substance P at the first synapse of the baroreceptor reflex

Naunyn-Schmiedeberg's Archives of Pharmacology
G Haeusler, R Osterwalder

Abstract

There is evidence that the undecapeptide substance P is the transmitter released from pain fibres in the dorsal horn of the spinal cord. This, in turn, suggested to use the possibility of a similar role for substance P in another type of primary sensory structure, namely the baroreceptor neurones which terminate in the bulbar nucleus of the solitary tract (NTS). Substance P, injected into a lateral brain ventricle of urethane-anaesthetized rats, caused dose-dependent increases in blood pressure and heart rate. By contrast, local application of substance P to the region of the NTS, using small pieces of filter paper soaked in substance P-containing solution, resulted in hypotension and bradycardia. In cats anaesthetized with urethane, the same procedure also decreased blood pressure, heart rate and spontaneous sympathetic nervous activity. Release of substance P from nerve endings, through local application of capsaicin to the NTS, produced cardiovascular effects which were indistinguishable from those of substance P. A combined cannula-electrode with an uninsulated tip enabled identification of sites in the NTS of rats and cats, where electrical stimulation elicited decreases in blood pressure, heart rate and spontaneous sympat...Continue Reading

References

Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·M Otsuka, S Konishi
Jan 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseA C Cuello
Jan 1, 1977·Progress in Brain Research·G Haeusler
Mar 1, 1978·The Journal of Comparative Neurology·A C Cuello, I Kanazawa
Dec 1, 1978·Acta Physiologica Scandinavica·J M LundbergS Said
Jul 6, 1979·Brain Research·E TheriaultT Jessell
Aug 13, 1979·Life Sciences·R GamseF Lembeck
May 6, 1977·Pflügers Archiv : European journal of physiology·D Jordan, K M Spyer
Jan 1, 1977·Pharmacology· Pham-Huu-ChanhW Lehmann-Schad
Oct 15, 1977·European Journal of Pharmacology·R W Bury, M L Mashford
Feb 1, 1975·Acta Physiologica Scandinavica·D Hallberg, B Pernow
Jun 1, 1975·Canadian Journal of Physiology and Pharmacology·J L HenryM E Morris
Jan 1, 1975·Acta Physiologica Scandinavica·B Pernow, S Rosell
Jan 1, 1976·Life Sciences·W de Jong, M Palkovits
May 14, 1976·Brain Research·J Davies, A Dray
Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·G HaeuslerA Huerlimann
Mar 29, 1974·Brain Research·J W Phillis, J J Limacher
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris
Jul 1, 1969·The American Journal of Physiology·M Miura, D J Reis
Jan 1, 1980·Annual Review of Neuroscience·R A NicollS E Leeman
Feb 4, 1963·Annals of the New York Academy of Sciences·K VOGLERK H BERNEIS

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Citations

May 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·T BramhallF Lembeck
Jul 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J Donnerer, F Lembeck
May 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, J Donnerer
May 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseJ M Lundberg
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·G Jancsó, G Such
Aug 13, 1982·European Journal of Pharmacology·M Petty, J Reid
Dec 1, 1991·Respiration Physiology·M A HaxhiuN S Cherniack
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·E BarocelliG de Caro
Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Apr 1, 1984·Journal of the Autonomic Nervous System·F Barja, R Mathison
Feb 1, 1985·Journal of the Autonomic Nervous System·P R Howe
Dec 1, 1987·Journal of the Autonomic Nervous System·D S KnightT S Fournet
Nov 1, 1989·Journal of the Autonomic Nervous System·M A HaxhiuN S Cherniack
Feb 9, 1995·Journal of the Autonomic Nervous System·F MartiniJ J Puizillout
Jan 1, 1985·Peptides·J EimerlG Feuerstein
Apr 29, 1983·Neuroscience Letters·G TerenghiJ M Polak
Sep 30, 1985·Neuroscience Letters·M Ferguson, C Bell

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