Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus

Endocrinology
A Sahu

Abstract

Leptin (OB protein) reduces food intake by acting at the hypothalamic level. The purpose of the present study was to identify potential targets of leptin signaling in the hypothalamus in ad-lib fed rats. Central administration of leptin (5 microg) for 3 days decreased food intake and body weight gain in association with a decrease in hypothalamic galanin (GAL), melanin-concentrating hormone (MCH), proopiomelanocortin (POMC) and neuropeptide Y (NPY) gene expression and with an increase in neurotensin (NT) gene expression. In pair-fed rats, NPY gene expression was increased and there was no change in either MCH, GAL, POMC or NT gene expression. This study identifies GAL, MCH, POMC and NT as non-NPY targets of leptin signaling and suggests that leptin's action on food intake and body weight is most likely mediated by inhibiting excitatory (e.g. NPY, MCH, GAL, POMC) and stimulating inhibitory (e.g., NT) signals in the feeding circuitry.

Citations

Mar 17, 2004·Molecular and Cellular Biology·J G HohmannR A Steiner
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dawna Salter-Venzon, Alan G Watts
Jan 15, 2011·Journal of Nutrition and Metabolism·Soundararajan KamalakkannanMohammad A Akbarsha
Mar 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Amanda LaqueHeike Münzberg
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Dennis K LeeBrian F O'Dowd
Nov 26, 2010·Endocrinology and Metabolism Clinics of North America·Katherine A Simpson, Stephen R Bloom
Mar 21, 2009·Physiology & Behavior·Catherine B Lawrence
Jul 22, 2008·Behavioural Brain Research·Eun Ran KimTooru M Mizuno
Aug 6, 2003·Journal of Neuroendocrinology·Z StepanyanW Meyerhof
Jul 24, 2004·Animal Reproduction Science·C R Barb, R R Kraeling
May 26, 2004·Physiology & Behavior·Gareth WilliamsJoanne A Harrold
May 12, 2004·Peptides·Sarah F Leibowitz, Katherine E Wortley
Mar 6, 2015·Frontiers in Systems Neuroscience·Juliette A BrownGina M Leinninger
May 31, 2016·Theriogenology·Marina R S FortesMilton G Thomas
Jan 1, 1999·Nutritional Neuroscience·D S Roane, J K Bounds
Sep 25, 2004·Medicinal Research Reviews·Josep M ArgilésFrancisco J López-Soriano
Aug 26, 1998·FEBS Letters·J López-SorianoJ M Argilés
Dec 23, 1999·Current Opinion in Neurobiology·C B LawrenceN J Rothwell
Jul 30, 2003·Expert Opinion on Therapeutic Targets·Guillaume Hervieu
Feb 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D G BaskinJ P Kochan
Dec 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Pierre RuffinGertjan van Dijk
Nov 24, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y L LiuM J Stock
Apr 9, 1999·Nature Neuroscience·J D GardnerG N Luheshi

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